7019-01-4

Basic information

• Product Name: 4-(PHENYLSULFONYL)ANILINE
• Synonyms: 4-(PHENYLSULFONYL)ANILINE;[4-(Phenylsulfonyl)phenyl]aMine;4-(Benzenesulphonyl)phenylaMine;4-AMinodiphenyl Sulfone;4-AMinophenyl Phenyl Sulfone;p-(Phenylsulfonyl)aniline;p-AMinodiphenyl Sulfone;p-AMinophenyl Phenyl Sulfone
• CAS NO: 7019-01-4
• Molecular Formula: C₁₂H₁₁NO₂S
• Molecular Weight: 233.29
• Product Categories: Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 7019-01-4.mol
• Article Data: 27

Chemical Properties

• Melting Point: 175-177°C
• Appearance: /
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-(PHENYLSULFONYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PHENYLSULFONYL)ANILINE(7019-01-4)
• EPA Substance Registry System: 4-(PHENYLSULFONYL)ANILINE(7019-01-4)

Safety Data

• Hazardous Substances Data: 7019-01-4(Hazardous Substances Data)

Usage

Description

4-(Phenylsulfonyl)aniline, also known as 4-(phenylsulfonyl)benzenamine, is an organic compound with the molecular formula C12H11NO2S. It is a derivative of aniline, featuring a phenylsulfonyl group attached to the para position of the aniline molecule. 4-(PHENYLSULFONYL)ANILINE is known for its chemical reactivity and is often utilized as a building block in the synthesis of various pharmaceuticals and organic compounds.

Uses

Used in Pharmaceutical Industry:
4-(Phenylsulfonyl)aniline is used as a key intermediate in the synthesis of novel Flufenamic acid analogues. These analogues serve as inhibitors of androgen receptor-mediated transcription, which can be beneficial in the development of treatments for conditions related to androgen receptor activity, such as certain types of cancer and hormonal disorders.

Upstream product

• 1146-39-0 4-nitrophenyl phenyl sulfone 
• 21849-33-2 (4-benzenesulfonyl-phenyl)-carbamic acid ethyl ester 
• 107920-73-0 N-(4-(phenylsulfonyl)phenyl)acetamide 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 952-97-6 4-nitrophenyl phenyl sulfide 
• 121-57-3 4-aminobenzene sulfonic acid 
• 71-43-2 benzene 
• 135218-54-1 C₁₂H₁₁NO₂S*C₄₂H₇₀O₃₅ 
• 108-90-7 chlorobenzene 
• 80-07-9 4,4'-dichlorodiphenyl sulphone 
• 80-00-2 4-Chlorophenyl phenyl sulfone 
• 17051-72-8 (o-chlorophenyl)phenylsulfone 
• 80-09-1 4,4'-sulfonediphenol 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 3112-94-5 N,N-dimethyl-4-(phenylsulfonyl) aniline 
• 7402-69-9 p-hydroxyphenyl p-tolyl sulfone 
• 107920-73-0 N-(4-(phenylsulfonyl)phenyl)acetamide 
• 34452-72-7 4-benzenesulfonyl-N-sulfinyl-aniline 
• 94331-10-9 (4-benzenesulfonyl-phenyl)-phenyl-diazene 
• 117847-21-9 4-(4-Benzenesulfonyl-phenylamino)-benzonitrile 
• 258848-37-2 4-{5-[(4-benzenesulfonyl-phenylamino)-methyl]-2-methyl-imidazol-1-ylmethyl}-benzonitrile 
• 871306-95-5 6-fluoro-4-(4-(phenylsulfonyl)phenylamino)-1,7-naphthyridine-3-carbonitrile 
• 808734-39-6 (4-benzenesulfonyl-phenyl)-(5-chloro-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-amine 
• 2493-66-5 2-nitro-4-phenylsulfonylphenol 
• 70415-93-9 1,4-bis-benzenesulfonyl-2-nitro-benzene 
• 39070-66-1 2-nitro-4-(phenylsulphonyl)aniline 

Relevant articles and documents

Synthesis of Sulfones and Sulfonyl Derivatives using Sodium (tert-butyldimethylsilyl)oxymethanesulfinate

The present invention relates to a method for manufacturing a sulfone and sulfonyl derivative compound using sodium (tert-butyldimethylsilyl)oxymethanesulfinate, which is a novel organic sulfin salt, wherein the novel organic sulfin salt has good stability, environmental friendliness and economy, and is easy to handle, and thus significantly reduces the amount of transition metal catalysts and the amount of organic sulfin salts used when introducing aryl or alkenyl. Also, alkylation, arylation, amination, and fluorination are all possible during secondary functionalization. Therefore, the present invention can be usefully used in preparation and mass production of various kinds of sulfones and derivatives thereof including asymmetric sulfone derivatives.

Method for synthesizing sulfone compounds under photocatalysis condition

The invention belongs to the technical field of compound preparation, and particularly relates to a method for synthesizing sulfone compounds under a photocatalysis condition. Aromatic hydrazine and sulfinate are used as raw materials, and under the action of alkali and a solvent, a sulfone compound is generated through reaction under the condition of air or oxygen under the illumination of visible light. According to the method disclosed by the invention, aryl hydrazine is used as an arylation reagent, polyacid salt is used as a catalyst or an organic photosensitizer is used as a catalyst, and the sulfones compound can be efficiently synthesized by coupling with sulfinate under the condition of room temperature through visible light irradiation. The method has good substrate universalityand relatively mild reaction conditions, is not only a substitute for synthesizing sulfone compounds by coupling from simple substrates reported at present, but also broadens the new application of the polyacid salt in the field of photocatalysis.

SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF

The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.