70289-12-2 Usage
Description
2-Ethoxyphenylacetic Acid is an organic compound that serves as a versatile reactant in various chemical syntheses, particularly for the production of enzyme inhibitors. It is also utilized in the development of engineered myoglobins, where hemin iron is replaced by various abiological noble metals to create novel metalloenzymes.
Uses
Used in Chemical Synthesis Industry:
2-Ethoxyphenylacetic Acid is used as a reactant for synthesizing enzyme inhibitors, which are essential in various applications such as pharmaceuticals and biotechnology.
Used in Bioengineering and Enzyme Design:
2-Ethoxyphenylacetic Acid is used as a reactant in engineered myoglobins, where hemin iron is replaced by various abiological noble metals. This process results in the creation of novel metalloenzymes that catalyze carbene insertion into C-H bonds, as well as carbene addition to vinylarenes and aliphatic α-olefins, showcasing its potential in the field of bioengineering and enzyme design.
Check Digit Verification of cas no
The CAS Registry Mumber 70289-12-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,2,8 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 70289-12:
(7*7)+(6*0)+(5*2)+(4*8)+(3*9)+(2*1)+(1*2)=122
122 % 10 = 2
So 70289-12-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O3/c1-2-13-9-6-4-3-5-8(9)7-10(11)12/h3-6H,2,7H2,1H3,(H,11,12)
70289-12-2Relevant articles and documents
Improved, gram-scale synthesis of sildenafil in water using arylacetic acid as the acyl source in the pyrazolo[4,3-d]pyrimidin-7-one ring formation
Laha, Joydev K.,Gulati, Upma,Saima,Gupta, Anjali,Indurthi, Harish Kumar
supporting information, p. 2643 - 2648 (2021/02/16)
An improved, gram-scale synthesis of the blockbuster drug sildenafil, used for the treatment of male erectile dysfunction, has been developed. Unlike the previous literature, the current method demonstrates the use of arylacetic acid as an acyl source, a cheap oxidant K2S2O8, and water as the reaction medium in the key step of pyrrazolo[4,3-d]pyrimidin-7-one ring formation. As well as being a green and benign approach, the current method reduces the cost by half compared to our previous strategy. In addition, the general relevance of the method has been demonstrated in the synthesis of a variety of quinazolinone and benzothiazole derivatives with excellent functional group tolerance.
