70382-09-1

Basic information

• Product Name: N-dodecyl-4-hydroxy-3-nitrobenzamide
• Synonyms: N-dodecyl-4-hydroxy-3-nitrobenzamide
• CAS NO: 70382-09-1
• Molecular Weight: 350.458
• Mol File: 70382-09-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-dodecyl-4-hydroxy-3-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-dodecyl-4-hydroxy-3-nitrobenzamide(70382-09-1)
• EPA Substance Registry System: N-dodecyl-4-hydroxy-3-nitrobenzamide(70382-09-1)

Safety Data

• Hazardous Substances Data: 70382-09-1(Hazardous Substances Data)

Upstream product

• 124-22-1 n-Dodecylamine 
• 616-82-0 3-nitro-4-hydroxybenzoic acid 

Relevant articles and documents

Calcium-Responsive Liposomes via a Synthetic Lipid Switch

Liposomal drug delivery would benefit from enhanced control over content release. Here, we report a novel avenue for triggering release driven by chemical composition using liposomes sensitized to calcium—a target chosen due to its key roles in biology and disease. To demonstrate this principle, we synthesized calcium-responsive lipid switch 1, designed to undergo conformational changes upon calcium binding. The conformational change perturbs membrane integrity, thereby promoting cargo release. This was shown through fluorescence-based release assays via dose-dependent response depending on the percentage of 1 in liposomes, with minimal background leakage in controls. DLS experiments indicated dramatic changes in particle size upon treatment of liposomes containing 1 with calcium. In a comparison of ten naturally occurring metal cations, calcium provided the greatest release. Finally, STEM images showed significant changes in liposome morphology upon treatment of liposomes containing 1 with calcium. These results showcase lipid switches driven by molecular recognition principles as an exciting avenue for controlling membrane properties.