70459-07-3 Usage
Description
6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid is a fluoroquinolone antibiotic, a semi-synthetic derivative of the natural compound nalidixic acid. It possesses a broad-spectrum activity against both gram-positive and gram-negative bacteria, making it a versatile treatment option for various bacterial infections.
Used in Pharmaceutical Industry:
6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid is used as an antibiotic for treating a variety of bacterial infections. It works by inhibiting the enzymes responsible for DNA replication and repair in bacteria, ultimately leading to their death.
Used in Urinary Tract Infections Treatment:
6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid is used as a therapeutic agent for urinary tract infections due to its effectiveness against the bacteria causing these infections.
Used in Respiratory Tract Infections Treatment:
6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid is used as a treatment for respiratory tract infections, providing a broad-spectrum coverage against the bacteria responsible for such infections.
Used in Skin Infections Treatment:
6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid is used as a medication for skin infections, targeting the bacteria that cause these conditions.
Used in Serious Infections Treatment:
Due to its broad-spectrum activity, 6-Fluoro-1,4-dihydro-1-methyl-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid is used as a last-resort antibiotic for the treatment of serious infections when other antibiotics are not suitable. However, its use is cautious due to the potential for serious side effects, such as tendon damage and central nervous system effects.
Check Digit Verification of cas no
The CAS Registry Mumber 70459-07-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,4,5 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 70459-07:
(7*7)+(6*0)+(5*4)+(4*5)+(3*9)+(2*0)+(1*7)=123
123 % 10 = 3
So 70459-07-3 is a valid CAS Registry Number.
70459-07-3Relevant articles and documents
Developing ciprofloxacin analogues against plant DNA gyrase: A novel herbicide mode of action
Wallace, Michael D.,Waraich, Nidda F.,Debowski, Aleksandra W.,Corral, Maxime G.,Maxwell, Anthony,Mylne, Joshua S.,Stubbs, Keith A.
, p. 1869 - 1872 (2018/02/23)
Ciprofloxacin has been shown to exhibit potent herbicidal activity through action against plant DNA gyrase, presenting a novel mode of action. Analogues of ciprofloxacin have been prepared with increased herbicidal activity and diminished antibacterial activity, compared to ciprofloxacin, as demonstrated using model systems.
Structure-Activity Relationships of Antibacterial 6,7- and 7,8-Disubstituted 1-Alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids
Koga, Hiroshi,Itoh, Akira,Murayama, Satoshi,Suzue, Seigo,Irikura, Tsutomu
, p. 1358 - 1363 (2007/10/02)
Previous quantitative and qualitative structure-activity studies in antibacterial monosubstituted 1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids prompted us to synthesize the 6,7,8-polysubstituted compounds.In this paper, the preparation and antibacterial activity of the 6,7- and 7,8-disubstituted compounds and their derivatives are described.Among these compounds, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)quinoline-3-carboxylic acid (34) possessed many significant activities and was more active than oxolinic acid (84) against Gram-positive andGram-negative bacteria.Structure activity relationships are discussed.
