70460-18-3

Basic information

• Product Name: 3'-HYDROXYFLAVONE
• Synonyms: 3'-HYDROXYFLAVONE;4H-1-Benzopyran-4-one,2-(3-hydroxyphenyl)-(9CI);2-(3-hydroxyphenyl)chromen-4-one;2-(3-hydroxyphenyl)chromone;2-(3-hydroxyphenyl)-4H-chromen-4-one
• CAS NO: 70460-18-3
• Molecular Formula: C₁₅H₁₀O₃
• Molecular Weight: 238.24
• Product Categories: FLAVONE
• Mol File: 70460-18-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 206-208°C
• Boiling Point: 437.7°Cat760mmHg
• Flash Point: 170.9°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 2.86E-08mmHg at 25°C
• Refractive Index: 1.666
• PKA: 9.01±0.10(Predicted)
• CAS DataBase Reference: 3'-HYDROXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-HYDROXYFLAVONE(70460-18-3)
• EPA Substance Registry System: 3'-HYDROXYFLAVONE(70460-18-3)

Safety Data

• Hazardous Substances Data: 70460-18-3(Hazardous Substances Data)

Usage

Description

3'-Hydroxyflavone is a naturally occurring chemical compound that belongs to the flavonoid group. It is a derivative of flavone and is found in a variety of plants, including fruits, vegetables, and herbs. 3'-HYDROXYFLAVONE has been studied for its potential antioxidant, anti-inflammatory, and anticancer properties, as well as its potential as a neuroprotective agent. It has been investigated for its ability to inhibit certain enzymes and pathways involved in inflammation and cancer, and has been explored for its potential application in the treatment of neurodegenerative diseases, cardiovascular diseases, and metabolic disorders. Overall, research on 3'-hydroxyflavone suggests that it may have therapeutic potential in various disease conditions, making it an interesting chemical compound for further study and development.

Uses

Used in Pharmaceutical Industry:
3'-Hydroxyflavone is used as a therapeutic agent for its potential antioxidant, anti-inflammatory, and anticancer properties. It is being studied for its ability to inhibit certain enzymes and pathways involved in inflammation and cancer, which may contribute to the development of new treatments for various diseases.
Used in Neuroprotection:
3'-Hydroxyflavone is used as a neuroprotective agent due to its potential to protect neurons from damage and degeneration. It has been investigated for its potential application in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its protective effects could help slow down or prevent the progression of these conditions.
Used in Cardiovascular Disease Treatment:
3'-Hydroxyflavone is used as a treatment for cardiovascular diseases due to its potential to improve heart health and reduce the risk of heart-related complications. Its antioxidant and anti-inflammatory properties may contribute to the prevention and management of cardiovascular conditions.
Used in Metabolic Disorder Management:
3'-Hydroxyflavone is used in the management of metabolic disorders, such as diabetes and obesity, due to its potential to regulate metabolic processes and improve overall health. Its effects on inflammation and oxidative stress may help in the prevention and treatment of these disorders.

InChI:InChI=1/C15H10O3/c16-11-5-3-4-10(8-11)15-9-13(17)12-6-1-2-7-14(12)18-15/h1-9,16H

Upstream product

• 53906-83-5 3'-methoxyflavone 
• 85079-06-7 2-<(3-methoxybenzoyl)oxy>acetophenone 
• 1711-05-3 m-anisoyl chloride 
• 586-38-9 3-Methoxybenzoic acid 
• 84634-65-1 1-(2-hydroxyphenyl)-3-(3-methoxyphenyl)-1,3-propanedione 
• 121-71-1 3-Hydroxyacetophenone 
• 69404-96-2 methyl-2-<(tert-butyldimethylsilyl)oxy>benzoate 
• 119-36-8 methyl salicylate 
• 52600-91-6 1-(3-ethoxyphenyl)ethan-1-one 
• 7335-26-4 ethyl 2-methoxybenzoate 
• 34000-28-7 2'-hydroxy-3-methoxy-chalcone 
• 517892-03-4 3',4'-dihydroxyflavone-4'-β-D-glucopyranoside sodium salt 
• 517892-04-5 3',4'-dihydroxyflavone-4'-β-D-ribofuranoside sodium salt 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 119881-50-4 2-(3-acetoxy-phenyl)-6-diacetylamino-chromen-4-one 
• 405216-85-5 3'-(N,N-Dimethylcarbamoyloxy)flavone 

Relevant articles and documents

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.

Microwave-assisted synthesis of novel bis-flavone dimers as new anticancer agents

In this study, we describe a microwave-based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Synthesis and antiviral activity of 2-aryl-4H-chromen-4-one derivatives against Chikungunya virus

A series of nineteen 2-aryl-4H-chromen-4-one derivatives 2a-2s were synthesized and evaluated for their antiviral activity against Chikungunya virus (LR2006-OPY1) in Vero cell culture by CPE reduction assay. Three compounds 2a, 2b and 2g, were found to be active at concentration of (IC50) 0.44 μM, 0.45 μM and 2.02 μM, respectively. Compounds having heterocyclic ring 2a and 2b at the 2nd position of the chromenone were found to be potent inhibitor of ChikV. Cytotoxicity studies were performed using Vero cell culture, compounds 2a and 2b exhibited SI of ≥100. Molecular docking simulation has been carried out to understand the possible mechanism of action.