70529-36-1

Basic information

• Product Name: 4,5-bis-(4-chloro-phenyl)-2-trifluoromethyl-thiazole
• CAS NO: 70529-36-1
• Molecular Weight: 374.213
• Mol File: 70529-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,5-bis-(4-chloro-phenyl)-2-trifluoromethyl-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-bis-(4-chloro-phenyl)-2-trifluoromethyl-thiazole(70529-36-1)
• EPA Substance Registry System: 4,5-bis-(4-chloro-phenyl)-2-trifluoromethyl-thiazole(70529-36-1)

Safety Data

• Hazardous Substances Data: 70529-36-1(Hazardous Substances Data)

Upstream product

• 51490-05-2 1,2-bis(4-chlorophenyl)ethanone 
• 51324-24-4 2-bromo-1,2-bis-(p-chlorophenyl)-ethanone 
• 421-52-3 trifluorothioacetamide 

Relevant articles and documents

Synthesis and Platelet Aggregation Inhibitory Activity of 4,5-Bis(aryl)-2-substituted-thiazoles

In our continuing effort to discover compounds which inhibit collagen-induced platelet aggregation, we have screened compounds in a mouse pulmonary thromboembolism screen.Methyl 4,5-bis(4-methoxyphenyl)-2-thiazoleacetate (3) was very active in the above screen.However, 3 was active for less than 5 min when given orally to guinea pigs.As a result, our synthetic goal was to prepare 2-substituted thiazoles with a much longer duration of activity.This paper describes the preparation of a number 4,5-bis(aryl)-2-substituted-thiazoles and their in vitro and ex vivo activity against collagen-induced platelet aggregation.It was determined that 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)thiazole (16) is the most promising compound.