70558-05-3 Usage
Description
4-[(TetraMethyl-1,3,2-dioxaborolan-2-yl)Methyl]Morpholine is a boronic acid derivative that features a morpholine ring. It is a stable and versatile chemical compound widely used in organic synthesis and as a reagent in the production of pharmaceuticals and agrochemicals. 4-[(TetraMethyl-1,3,2-dioxaborolan-2-yl)Methyl]Morpholine is recognized for its utility as a building block in the synthesis of various organic compounds and has demonstrated potential as a ligand in metal-catalyzed reactions, making it a valuable tool in the field of organic chemistry.
Uses
Used in Organic Synthesis:
4-[(TetraMethyl-1,3,2-dioxaborolan-2-yl)Methyl]Morpholine is used as a building block for the synthesis of various organic compounds, contributing to the development of new drugs and innovative materials.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-[(TetraMethyl-1,3,2-dioxaborolan-2-yl)Methyl]Morpholine is used as a reagent in the production process, aiding in the creation of a wide range of medications.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, this compound is utilized as a reagent, playing a role in the development of agricultural chemicals that contribute to enhanced crop protection and yield.
Used as a Ligand in Metal-Catalyzed Reactions:
4-[(TetraMethyl-1,3,2-dioxaborolan-2-yl)Methyl]Morpholine also serves as a ligand in metal-catalyzed reactions, which is instrumental in advancing the field of organic chemistry and facilitating complex chemical transformations.
Check Digit Verification of cas no
The CAS Registry Mumber 70558-05-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,5,5 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 70558-05:
(7*7)+(6*0)+(5*5)+(4*5)+(3*8)+(2*0)+(1*5)=123
123 % 10 = 3
So 70558-05-3 is a valid CAS Registry Number.
70558-05-3Relevant articles and documents
Regioselective borylation of the C-H bonds in alkylamines and alkyl ethers. Observation and origin of high reactivity of primary C-H bonds beta to nitrogen and oxygen
Li, Qian,Liskey, Carl W.,Hartwig, John F.
supporting information, p. 8755 - 8765 (2014/07/07)
Borylation of aliphatic C-H bonds in alkylamines and alkyl ethers to form primary aminoalkyl and alkoxyalkyl boronate esters and studies on the origin of the regioselectivity of these reactions are reported. The products of these reactions can be used directly in Suzuki-Miyaura cross-coupling reactions or isolated as air-stable potassium trifluoroborate salts. Selective borylation of the terminal C-H bond at the positions β to oxygen and nitrogen occurs in preference to borylation of the other terminal C-H bonds. Experimental studies and computational results show that C-H bond cleavage is the rate-determining step of the current borylation reactions. The observed higher reactivity of C-H bonds at the terminal position of ethylamines and ethers results from a combination of attractive Lewis acid-base and hydrogen-bonding interactions, as well as typical repulsive steric interactions, in the transition state. In this transition state, the heteroatom lies directly above the boron atom of one boryl ligand, creating a stabilizing interaction between the weak Lewis acid and Lewis base, and a series of C-H bonds of the substrate lie near the oxygen atoms of the boryl ligands, participating in a set of weak C- H···O interactions that lead to significant stabilization of the transition state forming the major product.