70695-02-2 Usage
Description
Nargenicin A1 is a macrolide antibiotic that exhibits selective inhibitory activity against specific bacteria, including S. aureus, MRSA, and M. luteus, while showing minimal effects on a panel of 11 other Gram-positive and Gram-negative bacteria. It demonstrates dose-dependent inhibition of DnaE in S. aureus and E. coli, and possesses anti-inflammatory and immunomodulatory properties in murine BV-2 microglial cells. Additionally, nargenicin A1 exhibits potential in enhancing cell differentiation and reducing cell proliferation in HL-60 human myeloid leukemia cells, as well as displaying significant in vivo efficacy in reducing bacterial load in a murine model of S. aureus infection.
Uses
Used in Antibacterial Applications:
Nargenicin A1 is used as an antibiotic for its broad efficacy in selectively inhibiting the growth of S. aureus, MRSA, and M. luteus, with minimal effects on other bacteria. This selective action makes it a promising candidate for targeted treatment of bacterial infections, particularly those caused by antibiotic-resistant strains.
Used in Anti-inflammatory and Immunomodulatory Applications:
In murine BV-2 microglial cells, nargenicin A1 is used as an anti-inflammatory and immunomodulatory agent, inhibiting cytokine expression and nitric oxide production induced by LPS. This suggests its potential use in managing inflammatory conditions and modulating immune responses.
Used in Cancer Therapy:
Nargenicin A1 is used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid to reduce cell proliferation and increase cell differentiation in HL-60 human myeloid leukemia cells. This indicates its potential application in cancer therapy, particularly in the treatment of myeloid leukemia.
Used in In vivo Infection Models:
In a murine model of S. aureus infection, nargenicin A1 is used to reduce the number of colony-forming units (CFUs) in infected kidneys by 100,000-fold. This demonstrates its significant in vivo efficacy in treating bacterial infections and highlights its potential use in clinical settings for the treatment of such infections.
Check Digit Verification of cas no
The CAS Registry Mumber 70695-02-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,6,9 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 70695-02:
(7*7)+(6*0)+(5*6)+(4*9)+(3*5)+(2*0)+(1*2)=132
132 % 10 = 2
So 70695-02-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H37NO8/c1-13-11-14(2)28-17(12-20(34-5)27(33)35-23(13)16(4)30)8-9-18-21(28)22(31)15(3)24(25(18)37-28)36-26(32)19-7-6-10-29-19/h6-11,13,15-18,20-25,29-31H,12H2,1-5H3/b14-11+/t13-,15-,16-,17-,18-,20+,21+,22-,23+,24-,25+,28-/m1/s1
