707-36-8 Usage
Description
1-Chloro-3,5-dimethyladamantane is an adamantane derivative characterized by its rigid and compact structure, featuring a chloro group at the 1st carbon and methyl groups at the 3rd and 5th carbons. This organic compound is known for its stability and unique chemical properties, making it a versatile building block in various chemical syntheses and pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
1-Chloro-3,5-dimethyladamantane is used as a key intermediate for the synthesis of memantine hydrochloride, an FDA-approved drug for the treatment of Alzheimer's disease. It plays a crucial role in the development of this medication due to its structural and chemical properties that contribute to the drug's efficacy in addressing cognitive decline and other symptoms associated with Alzheimer's.
Used in Chemical Industry:
1-Chloro-3,5-dimethyladamantane is used as a building block in the preparation of organosilicon compounds with antiviral activity. Its unique structure and functional groups make it an ideal candidate for the development of new antiviral agents, potentially contributing to the fight against various viral infections.
Additionally, as Memantine impurity C, 1-Chloro-3,5-dimethyladamantane is relevant in the quality control and regulatory aspects of memantine hydrochloride production, ensuring the safety and purity of the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 707-36-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 707-36:
(5*7)+(4*0)+(3*7)+(2*3)+(1*6)=68
68 % 10 = 8
So 707-36-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H19Cl/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8H2,1-2H3
707-36-8Relevant articles and documents
Improvement method for synthesis process of memantine hydrochloride
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, (2018/07/30)
The invention discloses an improvement method for a synthesis process of memantine hydrochloride; with 1,3-dimethyl adamantane as a raw material, 3,5-dimethyl-1-adamantanol is obtained through a bromination reaction and a hydrolysis reaction; 3,5-dimethyl-1-adamantanol is subjected to a chlorination reaction to obtain 1-chloro-3,5-dimethyl adamantane; and 1-chloro-3,5-dimethyl adamantane is subjected to an ammoniation reaction, acid hydrolysis and salt formation, and the target product of methamine hydrochloride is produced, wherein in the bromination reaction, the reaction molar ratio of 1,3-dimethyl adamantane and bromine is 1:1.1, the reaction is performed in dichloroethane, and after the hydrolysis reaction, an organic phase is separated and washed to remove bromine and washed and dried, and an obtained solution is directly used for a next reaction. The improvement method provided by the invention can improve the yield, increase reaction safety and reduce waste and waste water.
PROCESS FOR PREPARING MEMANTINE
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, (2008/06/13)
A process for preparing memantine or an acid addition salt of memantine comprises reacting 1-bromo-3,5-dimethyl adamantane with formamide to form 1-N-formyl-3,5-dimethyl adamantane.
