7084-29-9 Usage
Description
3'-Deoxy-5-methyluridine, also known as 5-methyl-3'-deoxyuridine, is a modified nucleoside that plays a crucial role in the biological study of stabilizing histone stem-loop-containing mRNAs. It incorporates chain-terminating nucleosides at the 3'-terminus, which aids in understanding the mechanisms of mRNA stability and regulation.
Uses
Used in Biological Research:
3'-Deoxy-5-methyluridine is used as a research tool for studying the stabilization of histone stem-loop-containing mRNAs. Its incorporation of chain-terminating nucleosides at the 3'-terminus helps researchers investigate the factors that contribute to mRNA stability and regulation, providing valuable insights into the underlying mechanisms.
Used in Drug Development:
3'-Deoxy-5-methyluridine can be utilized in the development of drugs targeting mRNA stability and regulation. By understanding the role of this modified nucleoside in stabilizing histone stem-loop-containing mRNAs, researchers can potentially develop therapeutic agents that modulate mRNA stability, leading to the treatment of various diseases associated with mRNA dysregulation.
Used in Diagnostic Applications:
3'-Deoxy-5-methyluridine may also find applications in diagnostic assays and techniques, where its ability to stabilize histone stem-loop-containing mRNAs can be leveraged to detect specific mRNA species or monitor changes in mRNA stability under different conditions. This can contribute to the early diagnosis and monitoring of diseases related to mRNA regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 7084-29-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,8 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7084-29:
(6*7)+(5*0)+(4*8)+(3*4)+(2*2)+(1*9)=99
99 % 10 = 9
So 7084-29-9 is a valid CAS Registry Number.
7084-29-9Relevant articles and documents
The Chemoenzymatic Synthesis of 2-Chloro- and 2-Fluorocordycepins
Denisova, Alexandra O.,Tokunova, Yulia A.,Fateev, Ilja V.,Breslav, Alexandra A.,Leonov, Vladimir N.,Dorofeeva, Elena V.,Lutonina, Olga I.,Muzyka, Inessa S.,Esipov, Roman S.,Kayushin, Alexey L.,Konstantinova, Irina D.,Miroshnikov, Anatoly I.,Stepchenko, Vladimir A.,Mikhailopulo, Igor A.
, p. 4853 - 4860 (2017/10/06)
Two approaches to the chemoenzymatic synthesis of 2-fluorocordycepin and 2-chlorocordycepin were studied: (i) the use of 3′-deoxyadenosine (cordycepin) and 3′-deoxyinosine (3′dIno) as donors of 3-deoxy- d -ribofuranose in the transglycosylation of 2-fluoro- (2F Ade) and 2-chloroadenine (2Cl Ade) catalyzed by the recombinant E. coli purine nucleoside phosphorylase (PNP), and (ii) the use of 2-fluoroadenosine and 3′-deoxyinosine as substrates of the cross-glycosylation and PNP as a biocatalyst. An efficient method for 3′-deoxyinosine synthesis starting from inosine was developed. However, the very poor solubility of 2Cl Ade and 2F Ade is the limiting factor of the first approach. The second approach enables this problem to be overcome and it appears to be advantageous over the former approach from the viewpoint of practical synthesis of the title nucleosides. The 3-deoxy-α- d -ribofuranose-1-phosphate intermediary formed in the 3′dIno phosphorolysis by PNP was found to be the weak and marginal substrate of E. coli thymidine (TP) and uridine (UP) phosphorylases, respectively. Finally, one-pot cascade transformation of 3-deoxy- d -ribose in cordycepin in the presence of adenine and E. coli ribokinase, phosphopentomutase, and PNP was tested and cordycepin formation in ca. 3.4% yield was proved.
