70892-82-9 Usage
Description
N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE, also known as BI-2, is a chemical compound with a molecular formula C15H20N2O4. It is a diol derivative of isonicotinamide, characterized by the presence of two hydroxyethyl groups attached to the nitrogen atom of the isonicotinamide ring. N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE is recognized for its chelating properties and its capacity to form stable complexes with metal ions, particularly transition metal ions, which positions it as a versatile agent in pharmaceutical and medicinal applications.
Uses
Used in Pharmaceutical Industry:
N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE is used as a chelating agent for its ability to bind with metal ions, which is crucial in stabilizing metal complexes and enhancing the solubility and bioavailability of metal-based drugs.
Used in Biochemical Applications:
In the realm of biochemistry, N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE is used as a ligand for metal ions, facilitating the study of metal ion interactions and their roles in biological systems.
Used in Treatment of Metal Ion-Related Diseases:
N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE is being studied for its potential role in the treatment of diseases associated with metal ion imbalances or toxicity, leveraging its chelating properties to mitigate the effects of such ions in the body.
Used in Drug Delivery Systems:
As a component of drug delivery systems, N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE is utilized to improve the delivery and targeting of therapeutic agents, particularly those involving metal ions, thereby potentially enhancing the efficacy and reducing the side effects of treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 70892-82-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,8,9 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 70892-82:
(7*7)+(6*0)+(5*8)+(4*9)+(3*2)+(2*8)+(1*2)=149
149 % 10 = 9
So 70892-82-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O3/c13-7-5-12(6-8-14)10(15)9-1-3-11-4-2-9/h1-4,13-14H,5-8H2
70892-82-9Relevant articles and documents
Silver-coordination polymer network combining antibacterial action and shape memory capabilities
Wang, Lin,Wang, Wenxi,Di, Shubin,Yang, Xifeng,Chen, Hongmei,Gong, Tao,Zhou, Shaobing
, p. 32276 - 32282 (2014/08/18)
In this study, a multifunctional polymer network is achieved by first synthesizing an isonicotinate-functionalized polyester (PIE) via classical melt-condensation polymerization, and secondly, the pendant of the pyrazinamide groups on the polyester side chains is coordinated with Ag ions to form a physically cross-linked network. Thermo property analysis and dynamic mechanical analysis reveal that the Ag-coordination polymer network possesses an excellent thermo-induced shape memory function, both under air and physiological conditions, due to a wide glass transition temperature region. The Ag ion concentration coordinated with the polymer was optimized to achieve the best shape memory effect using atomic absorption spectrometry. Moreover, the coordinated polyester can act as a reservoir of bactericidal Ag ions, in which the Ag ions are released and measured with inductively coupled plasma mass spectrometry, and in turn the antibacterial function is realized. Finally, the result of an Alamar blue assay reveals that the Ag-coordinated polyester has good cytocompatibility despite the introduction of a certain amount of Ag ions. Therefore, the multifunctional polymer has great potential applications in the biomedical field, e.g., burn wound dressings. the Partner Organisations 2014.
