71271-62-0

Basic information

• Product Name: 1-(6-methylpyridin-2-yl)propan-2-amine
• CAS NO: 71271-62-0
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.2209
• Mol File: 71271-62-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 228.84°C at 760 mmHg
• Flash Point: 112.829°C
• Density: 0.986g/cm³
• Vapor Pressure: 0.072mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 1-(6-methylpyridin-2-yl)propan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-methylpyridin-2-yl)propan-2-amine(71271-62-0)
• EPA Substance Registry System: 1-(6-methylpyridin-2-yl)propan-2-amine(71271-62-0)

Safety Data

• Hazardous Substances Data: 71271-62-0(Hazardous Substances Data)

Usage

General Description

1-(6-methylpyridin-2-yl)propan-2-amine is a chemical compound that belongs to the class of amines. Its molecular structure consists of a methylpyridinyl group attached to a propan-2-amine backbone. 1-(6-methylpyridin-2-yl)propan-2-amine is commonly used in pharmaceutical research and drug development due to its potential therapeutic properties. It may have applications in the treatment of various medical conditions, including neurological disorders and psychiatric diseases. Additionally, 1-(6-methylpyridin-2-yl)propan-2-amine may be used as a building block in the synthesis of other chemical compounds or as a reagent in organic chemistry reactions. Overall, this chemical shows promise for both research and industrial applications.

Synthetic route

1-(6-methylpyridin-2-yl)-2-propanone (65702-08-1) + formamide (77287-34-4, 77287-35-5, 60100-09-6) → 1-methyl-2-(6-methyl-pyridin-2-yl)-ethylamine (71271-62-0)

Conditions	Yield
With formic acid Erwaermen des Reaktionsprodukts mit konz. wss. HCl;

2,6-dimethylpyridine (108-48-5) → 1-methyl-2-(6-methyl-pyridin-2-yl)-ethylamine (71271-62-0)

Conditions	Yield
Multi-step reaction with 2 steps 1: phenyl lithium; diethyl ether / Weiteren Erwaermen mit Acetonitril in Aether und anschliessenden Behandeln mit wss.HCl 2: formic acid / Erwaermen des Reaktionsprodukts mit konz. wss. HCl View Scheme

Upstream product

• 108-48-5 2,6-dimethylpyridine 
• 65702-08-1 1-(6-methylpyridin-2-yl)propan-2-one 
• 77287-34-4 formamide 

Relevant articles and documents

Heterocyclic analogs of amphetamine: Thioureas, dithiocarbamates, and negatively substituted amides

A series of heterocyclic analogs of amphetamine was synthesized. The heterocycles employed included the 2-furyl, 2-thienyl, 3-methyl-2 thienyl, 3-pyridyl, and 6-methyl-2-pyridyl rings. The aliphatic amine group was converted to the N-methylthiourea, dithiocarbamate, methanesulfonyl, trifluoromethanesulfonyl, and trifluoroacetyl functions since similar conversions of the β-phenethylamine structure had shown blood pressure-lowering effects and some loss of behavioral effects. P-Chlorophenyl and 1-naphthyl analogs were also converted to these derivatives. Behavioral and other biological effects, including antiarthritic, passive cutaneous anaphylactic, and antimicrobial, were observed. The 3-methyl-2-thienyl analog of amphetamine significantly increased papillary muscle contractile force without producing arrhythmias.