7149-10-2Relevant articles and documents
Fabrication of ω-Transaminase@Metal-Organic Framework Biocomposites for Efficiently Synthesizing Benzylamines and Pyridylmethylamines
Chen, Lina,Ding, Yingying,Jiao, Qingcai,Liu, Junzhong,Yu, Jinhai,Zhang, Hongjuan,Zong, Weilu
, (2021/11/05)
In this study, ten ω-transaminases (ω-TAs) have been investigated to efficiently catalyze the synthesis of twenty-four functionalized benzylamines and pyridylmethylamines. We optimized the reactions, screened suitable amino donors and compared ω-transaminases activities for all aromatic aldehyde substrates. Under the optimized conditions, eighteen aromatic amines have been obtained with 60.4%–96.6% conversions and isolated only via simple extraction and recrystallization with 18.5%–81% yields on a preparative scale. Furthermore, we first immobilized the Bm-STA onto the MOFs via the physical adsorption to overcome the limitation of free enzyme and improve their industrial applications. The obtained Bm-STA/UiO-66-NH2 composites exhibited not only high enzymes loading (80.4 mg g?1) and enzyme activity recovery (95.8%), but also the better reusability, storage stability, pH stability and the tolerance to acetone and DMF.
Efficient hydrogenation of benzaldoximes and Schiff bases on ceramic high-porosity palladium catalysts
Ignatov,Varakutin,Solov’eva,Karmanova,Kozlov,Semenova,Semenov
, p. 1394 - 1400 (2018/10/31)
An efficient catalytic method for the synthesis of benzyl- and dibenzylamines by hydrogenating oximes and Schiffbases was developed on palladium supported high-porosity foamed ceramic block catalyst. The multiple regeneration ability of the foamed ceramic block catalyst can significantly decrease the Pd consumption as compared to the use of the conventional 10%Pd/C catalyst. Owing to a high hardness of the foamed ceramic catalyst, the reaction mixture can rapidly be removed from the reactor without using filtering devices. The structures produced by the reaction are fragments of biologically active and natural molecules. Antiproliferative properties of dibenzylamines revealed on the sea urchin embryo model suggest that these compounds can be considered as promising agents for the design of new anticancer drugs.
Preparation method for vanillylamine hydrochloride
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Paragraph 0017-0028, (2017/09/02)
The invention discloses a preparation method for vanillylamine hydrochloride. The preparation method comprises the following steps: adding 3-methoxy-4-hydroxybenzaldehyde oxime into a reaction container, then adding alcohol and a composite catalyst, introducing hydrogen under a normal pressure condition for protection and carrying out heating for a reaction; and carrying out filtering after the reaction, adding hydrochloric acid with mass percentage concentration of 30% into a filtrate, adjusting the pH value of the filtrate to 1, filtering out a precipitated white crystal and carrying out vacuum drying so as to obtain finished vanillylamine hydrochloride. The method provided by the invention is simple in operation process, low in cost, high in yield, low in reaction conditions, high in product purity and environment-friendly. The method can overcome the disadvantages that a direct reduction and amination method for production of vanillylamine hydrochloride from ammonium formate has low yield, usage of a high-pressure reaction leads to great danger, usage of precious metals as catalysts results in high investment and the like in the prior art.