7162-59-6Relevant articles and documents
Multicolor Fluorescent Polymers Inspired from Green Fluorescent Protein
Deng, Hongping,Su, Yue,Hu, Minxi,Jin, Xin,He, Lin,Pang, Yan,Dong, Ruijiao,Zhu, Xinyuan
, p. 5969 - 5979 (2015)
Mimicking the green fluorescent protein (GFP), multicolor fluorescent polymers possessing enhanced fluorescence have been developed and applied to single-excitation cell imaging. The GFP core chromophore was covalently linked to the azide-functionalized a
Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants
Robertson, Linsey,Hartley, Richard C.
experimental part, p. 5284 - 5292 (2009/11/30)
The generation of excess reactive oxygen species (ROS) in mitochondria is responsible for much of the oxidative stress associated with ageing (aging), and mitochondrial dysfunction is part of the pathology of neurodegeneration and type 2 diabetes. Lipophilic pyridinium ions are known to accumulate in mitochondria and this paper describes a general route for the preparation of nitrone-containing N-arylpyridinium salts having a range of lipophilicities, as potential therapeutic antioxidants. The compatibility of nitrones with the Zincke reaction is the key to their synthesis. Their trapping of carbon-centred radicals and the EPR spectra of the resulting nitroxides are reported.
Quantitative structure-activity relationships of 2,4-diamino-5-(2-X- benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase
Selassie, Cynthia Dias,Gan, Wei-Xi,Kallander, Lara S.,Klein, Teri E.
, p. 4261 - 4272 (2007/10/03)
Quantitative structure-activity relationships (QSAR) have been formulated for a set of 15 2,4-diamino-5-(2-X-benzyl)pyrimidines versus dihydrofolate reductase from Lactobacillus casei and chicken liver. QSARs were also developed for comprehensive data sets containing mono-, di-, and trisubstituted benzyl derivatives. Particular emphasis was placed on the role played by ortho substituents in the overall binding process and subsequent inhibition of the catalytic process in both the prokaryotic and eucaryotic DHFRs. Comparisons between the two QSARs reveal subtle differences at specific positions which can be optimized to design more selective antibacterial agents.