71730-43-3

Basic information

• Product Name: 5-TERT-BUTYL-3-CHLORO-2-HYDROXY-BENZALDEHYDE
• Synonyms: 3-Chloro-5-tert-butylsalicylaldehyde;AKOS BB-6945;5-TERT-BUTYL-3-CHLORO-2-HYDROXY-BENZALDEHYDE;5-tert-butyl-3-chloro-2-hydroxyben
• CAS NO: 71730-43-3
• Molecular Formula: C₁₁H₁₃ClO₂
• Molecular Weight: 212.67
• Mol File: 71730-43-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 253°C at 760 mmHg
• Flash Point: 106.8°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 0.0117mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-TERT-BUTYL-3-CHLORO-2-HYDROXY-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-TERT-BUTYL-3-CHLORO-2-HYDROXY-BENZALDEHYDE(71730-43-3)
• EPA Substance Registry System: 5-TERT-BUTYL-3-CHLORO-2-HYDROXY-BENZALDEHYDE(71730-43-3)

Safety Data

• Hazardous Substances Data: 71730-43-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 12, p. 847, 1982 DOI: 10.1080/00397918208065962

InChI:InChI=1/C11H13ClO2/c1-11(2,3)8-4-7(6-13)10(14)9(12)5-8/h4-6,14H,1-3H3

Upstream product

• 98-28-2 2-chloro-4-tert-butylphenol 
• 76-05-1 trifluoroacetic acid 
• 58456-93-2 2-(aminomethyl)-6-chloro-4-(1,1-dimethylethyl)phenol 

Downstream Products

• 71064-05-6 3-chloro-5-tert.butylsalicylaldehyde oxime 
• 102022-03-7 (5-tert-butyl-7-chloro-benzofuran-2-yl)-phenyl ketone 
• 114279-40-2 (5-tert-butyl-7-chloro-benzofuran-2-yl)-(4-chloro-phenyl)-ketone-(2,4-dinitro-phenylhydrazone) 
• 102316-10-9 (5-tert-butyl-7-chloro-benzofuran-2-yl)-phenyl ketone semicarbazone 
• 85943-56-2 5-tert-Butyl-3-chloro-2-hydroxy-benzonitrile 
• 81440-74-6 N-<<3-chloro-5-(1,1-dimethylethyl)-2-hydroxyphenyl>methyl>sulfamide 
• 78335-95-2 2-(3-aminopropyl)-6-chloro-4-(1,1-dimethylethyl)phenol 
• 101868-57-9 (5-tert-butyl-7-chloro-benzofuran-2-yl)-(4-chloro-phenyl)-ketone 

Relevant articles and documents

BENZOPYRAN COMPOUNDS USEFUL FOR TREATING INFLAMMATORY CONDITIONS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (1). Wherein Z, X, R1, R2, R3, and R4 are as described in specification.

THE USE OF STERICALLY HINDERED BENZYLAMINES IN THE SOMMELET REACTION

A number of 2- and 2,6-disubstituted benzylamines have been successfully converted to the corresponding benzaldehydes via the Sommelet reaction in yields of 17-68percent.

2-(Aminomethyl)phenols, a New Class of Saluretic Agents. 3. Effects of Functional Group Reorientation and Modification

A series of modified 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects.Intravenous dog data are included as supplementary material to show that the diuretic responses, or lack thereof, may be obtained in a second species.Reorientation of the 2-(aminomethyl) group either meta or para to the hydroxyl substituent resulted in loss of diuretic effects.Similarly, replacement of either the phenolic hydroxyl or the aminomethyl group with other functional moieties substantially diminished saluretic effects.