71800-37-8 Usage
Description
(DES-ARG10,LEU9)-KALLIDIN is a peptide that belongs to the kinin family of vasoactive peptides. It is derived from kininogen, a plasma protein, and is a potent vasodilator and inducer of smooth muscle contraction. This peptide plays a role in the regulation of blood pressure, inflammation, and pain perception. It is also involved in the pathophysiology of various diseases including hypertension, heart failure, and renal dysfunction. Additionally, (DES-ARG10,LEU9)-KALLIDIN has been shown to exert its effects through interaction with specific receptors, leading to the activation of signaling pathways that mediate its biological actions. Overall, (DES-ARG10,LEU9)-KALLIDIN is an important molecule in the field of cardiovascular and inflammatory research with potential therapeutic implications.
Uses
Used in Cardiovascular Research:
(DES-ARG10,LEU9)-KALLIDIN is used as a research tool for studying the regulation of blood pressure, as it acts as a potent vasodilator and inducer of smooth muscle contraction.
Used in Inflammatory Research:
(DES-ARG10,LEU9)-KALLIDIN is used as a research tool for investigating its role in inflammation and pain perception, as well as its involvement in the pathophysiology of various diseases.
Used in Drug Development:
(DES-ARG10,LEU9)-KALLIDIN is used as a potential therapeutic target for the development of drugs aimed at treating hypertension, heart failure, and renal dysfunction, due to its involvement in these conditions and its interaction with specific receptors to activate signaling pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 71800-37-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,8,0 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 71800-37:
(7*7)+(6*1)+(5*8)+(4*0)+(3*0)+(2*3)+(1*7)=108
108 % 10 = 8
So 71800-37-8 is a valid CAS Registry Number.
71800-37-8Relevant articles and documents
Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment
Wong, Clarence T. T.,Rowlands, Dewi K.,Wong, Chi-Hang,Lo, Theodore W. C.,Nguyen, Giang K. T.,Li, Hoi-Yeung,Tam, James P.
, p. 5620 - 5624 (2012)
Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain. For example, the entire loop 6 of kalata B1 was replaced with the peptidic bradykinin B1 receptor antagonist DALK (red in scheme) to obtain the cyclic bradykinin antagonist ckb-kal. Copyright