7183-69-9 Usage
Description
14-Hydroxydihydrocodeine is a dihydro metabolite of the analgesic opiate codeine, which is an opioid used for pain management. It is a certified reference material categorized as an opioid and is intended for research and forensic applications.
Uses
Used in Pharmaceutical Industry:
14-Hydroxydihydrocodeine is used as an active pharmaceutical ingredient for the development of pain relief medications. It is utilized in the formulation of analgesic drugs to provide effective pain management and improve the quality of life for patients suffering from moderate to severe pain.
Used in Research and Forensic Applications:
14-Hydroxydihydrocodeine is used as a certified reference material in research and forensic applications. It serves as a standard for the identification, quantification, and quality control of opioid compounds in various analytical methods, such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). This helps in the accurate detection and measurement of opioids in biological samples, ensuring the reliability of test results and supporting forensic investigations.
Check Digit Verification of cas no
The CAS Registry Mumber 7183-69-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,8 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7183-69:
(6*7)+(5*1)+(4*8)+(3*3)+(2*6)+(1*9)=109
109 % 10 = 9
So 7183-69-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H23NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,11,13,16,20-21H,5-9H2,1-2H3/t11-,13+,16-,17-,18+/m0/s1
7183-69-9Relevant articles and documents
PEGYLATED OPIOID WITH LOW ADDICTIVE EFFECT
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Paragraph 0058; 0059, (2018/12/13)
Provided in the present invention are a conjugate of polyethylene glycol and opioid as shown in general formula (I), and a pharmaceutical composition comprising the conjugate. By means of covalently bonding a plurality of opioids to a polyethylene glycol derivative, the present invention improves water solubility and pharmacokinetic property of the drug with a low addictive effect. ????????PEG-(X-OP)m?????(I)
PROCESS FOR REDUCING THE 6-KETO GROUP OF A MORPHINAN ALKALOID TO THE 6-HYDROXY GROUP BY HYDROGENATION
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Page/Page column 5-6, (2011/04/13)
The present invention relates to a process for the reduction of a 6-keto group in a morphinan alkaloid to the corresponding 6-hydroxy group, comprising hydrogenating the 6-keto group using gaseous hydrogen in the presence of a heterogeneous catalyst and a solvent, to yield the 6-hydroxy morphinan alkaloid, wherein the reduction is carried out at a pH in the range of about 5 to about 7, and the 6-hydroxy morphinan alkaloid has an α:β ratio of > 85: 15.
IMPROVED PROCESS FOR THE PREPARATION OF 6-ALPHA-HYDROXY-N-ALKYLATED OPIATES
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Page/Page column 25, (2009/01/20)
The present invention is directed to the conversion of a 6-keto morphinan to a 6-alpha-hydroxy morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
