71849-99-5Relevant articles and documents
Synthesis of 2-Aminocarboxylic Acids on the Basis of Metalated Lithium Acylates
Zorin,Lenkova,Khachaturyan,Zorin
, p. 1590 - 1594 (2018/11/10)
2-Aminocarboxylic acids have been synthesized through the reaction of lithium acylate α-carbanions with alkyl nitrites to form α-hydroxyiminoacylates, followed by reduction of the latter with tin chloride. The reactions of lithium acylate α-carbanions, ge
A convenient synthesis of N-boc-protected α-aminonitriles from α-amidosulfones
Banphavichit, Vorawit,Chaleawlertumpon, Saowaluk,Bhanthumnavin, Worawan,Vilaivan, Tirayut
, p. 3147 - 3160 (2007/10/03)
Synthesis of N-Boc-protected α-aminonitriles starting from N-Boc-protected α-aminosulfones is described. Treatment of the sulfone with two equivalents of potassium cyanide in 2-propanol or dichloromethane- H2O under phase transfer condition affords crystalline N-Boc-protected α-aminonitriles in good yield. Hydrolysis of the aminonitriles provides a convenient access to racemic α-amino acids.
Asymmetric amino acid synthesis: Mitsunobu reaction on chiral cyanohydrins
Decicco, Carl P.,Grover, Paul
, p. 529 - 530 (2007/10/03)
BOC(SES)NH was reacted with chiral cyanohydrins using the Mitsunobu reaction to give good yields of protected α-aminonitriles, which were converted to chiral amino and imino acids.