72156-60-6Relevant articles and documents
Solvent-free peptide synthesis assisted by microwave irradiation: Environmentally benign synthesis of bioactive peptides
Mahindra, Amit,Patel, Neha,Bagra, Nitin,Jain, Rahul
, p. 3065 - 3069 (2014/01/06)
An efficient and facile, solvent-free peptide synthesis assisted by microwave irradiation, using DIC/HONB as the coupling reagent combination is reported. Key features of this original protocol are solvent-free synthesis, very short reaction time and scal
Histone deacetylase inhibitors: Synthesis of cyclic tetrapeptides and their triazole analogs
Singh, Erinprit K.,Nazarova, Lidia A.,Lapera, Stephanie A.,Alexander, Leslie D.,McAlpine, Shelli R.
supporting information; experimental part, p. 4357 - 4360 (2010/09/12)
Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described. HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated. The biological data demonstrate that incorporation of a triazole unit improves the HDAC inhibitory activity.
Selective inhibitors of the serine protease plasmin: Probing the S3 and S3′ subsites using a combinatorial library
Xue, Fengtian,Seto, Christopher T.
, p. 6908 - 6917 (2007/10/03)
A combinatorial library of 400 serine protease inhibitors with the general structure Cbz-Xaa-Trp-cyclohexanone-Trp-Yaa-OH has been constructed. The library was synthesized on the solid phase using mix-and-split synthesis, where 20 di
