72216-35-4

Basic information

• Product Name: 3-FLUOROBENZYLOXYBENZENE
• Synonyms: 1-BENZYLOXY-3-FLUORO-BENZENE;3-FLUOROBENZYLOXYBENZENE;3-FLUOROPHENOL BENZYL ETHER;3-(BENZYLOXY)FLUOROBENZENE;3-(Benzyloxy)fluorobenzene 98%;3-(Benzyloxy)fluorobenzene98%;3-FLUOROBENZYLOXYBENZENE 99%;1-fluoro-3-(phenoxyMethyl)benzene
• CAS NO: 72216-35-4
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.22
• Product Categories: blocks;FluoroCompounds
• Mol File: 72216-35-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 32-34°C
• Boiling Point: 185°C
• Flash Point: 68°C
• Appearance: /
• Density: 1.133g/cm³
• Vapor Pressure: 0.00469mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-FLUOROBENZYLOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUOROBENZYLOXYBENZENE(72216-35-4)
• EPA Substance Registry System: 3-FLUOROBENZYLOXYBENZENE(72216-35-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 72216-35-4(Hazardous Substances Data)

Usage

General Description

3-Fluorobenzyloxybenzene is an organic chemical compound with the molecular formula C13H11FO. It is a colorless liquid with a benzene ring structure and a fluorine atom attached to the benzene ring. 3-FLUOROBENZYLOXYBENZENE is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various functionalized molecules and as a precursor to create other fluorinated compounds. It is also utilized in research and development for its unique chemical properties and potential applications in drug discovery and material science. 3-Fluorobenzyloxybenzene is handled and stored under strict safety guidelines due to its potential hazardous properties and should be used by trained personnel in a controlled laboratory environment.

InChI:InChI=1/C13H11FO/c14-12-6-4-5-11(9-12)10-15-13-7-2-1-3-8-13/h1-9H,10H2

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 
• 100-51-6 benzyl alcohol 
• 372-20-3 3-fluorophenol 
• 100-39-0 benzyl bromide 
• 768-35-4 3-fluorophenylboronic acid 
• 3769-41-3 3-Benzyloxyphenol 
• 1195931-63-5 3-(benzyloxy)phenyl trifluoromethanesulfonate 
• 147460-41-1 2-bromo-5-fluorophenol 
• 372-18-9 1,3-Difluorobenzene 
• 35535-79-6 sodium m-fluoro phenoxide 
• 1528-74-1 4,4'-dinitrobiphenyl 
• 124-41-4 sodium methylate 
• 53087-13-1 3-(benzyloxy)phenyl bromide 

Downstream Products

• 372-20-3 3-fluorophenol 
• 185346-79-6 4-(benzyloxy)-1-bromo-2-fluorobenzene 

Relevant articles and documents

Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition

Fluorinated derivatives of radicamine A and radicamine B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities. Fluorinated derivatives of radicamine A and B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies revealed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom.

Silver-mediated fluorination of potassium aryltrifluoroborates with Selectfluor Dedicated to Professor Andrea Vasella on the occasion of his 71st birthday

A simple and practical procedure for the silver-mediated fluorination of aryl- and heteroaryltrifluoroborates with electrophilic fluorine from Selectfluor and LiOH·H2O is presented. The reaction procedure is simple and easy to set up, the process produces fluorinated arenes and heteroarenes in good to excellent yields and a wide range of electronically and structurally diverse substrates are tolerated.

One-pot, two-step, microwave-assisted palladium-catalyzed conversion of aryl alcohols to aryl fluorides via aryl nonaflates

A convenient procedure for converting aryl alcohols to aryl fluorides via aryl nonafluorobutylsulfonates (ArONf) is presented. Moderate to good one-pot, two-step yields were achieved by this nonaflation and microwave-assisted, palladium-catalyzed fluorination sequence. The reductive elimination step was investigated by DFT calculations to compare fluorination with chlorination, proving a larger thermodynamic driving force for the aryl fluoride product. Finally, a key aryl fluoride intermediate for the synthesis of a potent HCV NS3 protease inhibitor was smoothly prepared with the novel protocol.