72265-44-2

Basic information

• Product Name: erythro-2-quinuiclidinyl-2-(1-methylimidazolyl)carbinol
• CAS NO: 72265-44-2
• Molecular Weight: 221.302
• Mol File: 72265-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: erythro-2-quinuiclidinyl-2-(1-methylimidazolyl)carbinol(CAS DataBase Reference)
• NIST Chemistry Reference: erythro-2-quinuiclidinyl-2-(1-methylimidazolyl)carbinol(72265-44-2)
• EPA Substance Registry System: erythro-2-quinuiclidinyl-2-(1-methylimidazolyl)carbinol(72265-44-2)

Safety Data

• Hazardous Substances Data: 72265-44-2(Hazardous Substances Data)

Upstream product

• 52601-23-7 quinuiclidine-2-carboxylic acid hydrochloride 

Relevant articles and documents

Mono- and diaryl-2-quinuclidinylcarbinols with local anesthetic and antiarrhythmic activity

The reaction between 2-carboethoxyquinuclidine and various aryl- and heteroaryllithium reagents gave mixtures of aryl 2-quinuclidinyl ketones and diaryl-2-quinuclidinylcarbinols. Diborane reduction of the ketones gave the erythro-carbinols, stereochemically analogous to quinidine. Several of the mono- and diarylcarbinols exhibited potent local anesthetic and antiarrhythmic activity, in some cases greater than that of quinidine. Diphenyl-2-quinuclidinylcarbinol and a (bromomethoxyphenyl)(methoxyphenyl)-2-quinuclidinylcarbinol were particularly active in reverting ouabain-induced arrhythmia in dogs, showing a potency and duration of action equal to or greater than that of propranolol.