72475-12-8

Basic information

• Product Name: 2-(4-(tert-butyl)benzyl)-3-(4-(tert-butyl)phenyl)-2-methylpropanal
• Synonyms: 2-(4-(tert-butyl)benzyl)-3-(4-(tert-butyl)phenyl)-2-methylpropanal
• CAS NO: 72475-12-8
• Molecular Weight: 350.544
• Mol File: 72475-12-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-(tert-butyl)benzyl)-3-(4-(tert-butyl)phenyl)-2-methylpropanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(tert-butyl)benzyl)-3-(4-(tert-butyl)phenyl)-2-methylpropanal(72475-12-8)
• EPA Substance Registry System: 2-(4-(tert-butyl)benzyl)-3-(4-(tert-butyl)phenyl)-2-methylpropanal(72475-12-8)

Safety Data

• Hazardous Substances Data: 72475-12-8(Hazardous Substances Data)

Upstream product

• 18880-00-7 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene 
• 80-54-6 lilial 
• 19692-45-6 4-tert-butylbenzyl chloride 

Relevant articles and documents

Regio- and Diastereoselective [3+2] Annulation of Aliphatic Aldimines with Alkenes by Scandium-Catalyzed β-C(sp3)?H Activation

Here we report for the first time the regio- and diastereoselective [3+2] annulation of a wide range of aliphatic aldimines with alkenes via the activation of an unactivated β-C(sp3)?H bond by half-sandwich scandium catalysts. This protocol offers a straightforward and atom-efficient route for the synthesis of a new family of multi-substituted aminocyclopentane derivatives from easily accessible aliphatic aldimines and alkenes. The annulation of aldimines with styrenes exclusively afforded the 5-aryl-trans-substituted 1-aminocyclopentane derivatives with excellent diastereoselectivity through the 2,1-insertion of a styrene unit. The annulation of aldimines with aliphatic alkenes selectively gave the 4-alkyl-trans-substituted 1-aminocyclopentane products in a 1,2-insertion fashion. A catalytic amount of an appropriate amine such as adamantylamine (AdNH2) or dibenzylamine (Bn2NH) showed significant effects on the catalyst activity and stereoselectivity.