7250-67-1 Usage
Description
2-Pyrrolidinoethyl chloride hydrochloride, also known as 1-(2-Chloroethyl)pyrrolidine, is a haloalkyl substituted pyrrolidine derivative. It is a chemical compound with the molecular formula C6H12ClN and is characterized by the presence of a chloroethyl group attached to a pyrrolidine ring. 2-Pyrrolidinoethyl chloride hydrochloride is known for its reactivity and is commonly utilized in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
2-Pyrrolidinoethyl chloride hydrochloride is used as a key intermediate in the synthesis of pharmaceutical compounds. Its primary application is in the preparation of estrogen receptor antagonists, such as Nafoxidine (N212800) and its analogues. These compounds are used for the treatment of various hormone-dependent conditions, including certain types of cancer and endometriosis.
The use of 2-Pyrrolidinoethyl chloride hydrochloride in the pharmaceutical industry is attributed to its ability to react with other molecules, allowing for the creation of new compounds with specific therapeutic properties. Its reactivity and structural characteristics make it a valuable building block in the development of novel drugs targeting estrogen receptor-related diseases.
Purification Methods
Purify the hydrochloride by recrystallisation from isopropanol/di-isopropyl ether (charcoal) and recrystallise it twice more. The free base, b 55-56o/11mm, 60-63o/23mm and 90o/56mm, is relatively unstable and should be converted to the hydrochloride immediately, by dissolving in isopropanol and bubbling dry HCl through the solution at 0o, filtering off the hydrochloride and recrystallising it. The picrate has m 107.3-107.8o (from EtOH) [Cason J Org Chem 24 247 1959, Wright et al. J Am Chem Soc 70 3098 1948]. [Beilstein 20 III/IV 66.]
Check Digit Verification of cas no
The CAS Registry Mumber 7250-67-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,5 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7250-67:
(6*7)+(5*2)+(4*5)+(3*0)+(2*6)+(1*7)=91
91 % 10 = 1
So 7250-67-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H12ClN/c7-3-6-8-4-1-2-5-8/h1-6H2/p+1
7250-67-1Relevant articles and documents
Coumadin female phenol split-ring analogue and its medical use
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Paragraph 0033-0035, (2017/10/06)
The invention relates to the field of pharmaceutical chemistry, in particular to a coumestrol open-ring analogue with structures as shown in general formulae I and II and a medical application thereof, especially an application to the preparation of drugs as angiogenesis inhibition and vascular disruption agents.
INDENOISOQUINOLINONE DERIVATIVES, MANUFACTURING METHOD AND MEDICAL USE THEREOF
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Paragraph 0068; 0069, (2013/04/13)
Indenoisoquinolinone derivatives (I), the manufacturing method and the medical use thereof, which belong to pharmaceutical chemistry and organic chemistry field, are disclosed. These compounds can be used for treating several medical symptoms related to postmenopausal syndrome, uterine fibers deterioration and aortic smooth muscle cells proliferation, especially ER-(+) depend breast cancer. Meanwhile, these compounds can also be used for treating glioma and lung cancer, and have inhibiting effect on tumor metastasis effect on tumor metastasis.
Benzimidazolone antiviral agents
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, (2008/06/13)
The present invention concerns antiviral compounds, their compositions, and use in the treatment of viral infections. More particularly, the invention provides benzimidazolone derivatives for the treatment of respiratory syncytial virus infection.
