727726-34-3

Basic information

• Product Name: (2S)-1-[3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methyl-1-oxopropyl]-L-proline 1,1-dimethylethyl ester
• Synonyms: (2S)-1-[3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methyl-1-oxopropyl]-L-proline 1,1-dimethylethyl ester
• CAS NO: 727726-34-3
• Molecular Weight: 646.902
• Mol File: 727726-34-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S)-1-[3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methyl-1-oxopropyl]-L-proline 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-1-[3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methyl-1-oxopropyl]-L-proline 1,1-dimethylethyl ester(727726-34-3)
• EPA Substance Registry System: (2S)-1-[3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methyl-1-oxopropyl]-L-proline 1,1-dimethylethyl ester(727726-34-3)

Safety Data

• Hazardous Substances Data: 727726-34-3(Hazardous Substances Data)

Upstream product

• 775-12-2 diphenylsilane 
• 5497-76-7 L-proline tert-butyl ester hydrochloride 
• 727726-52-5 (2S)-3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methylpropanoic acid 
• 312-40-3 difluorodiphenylsilane 
• 2812-46-6 proline tert-butyl ester 
• 727726-43-4 2-[[1-[(2S)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione 
• 727726-45-6 [(2S)-2-methyl-3-(phenylmethoxy)-1-propyl][1-(benzoylamino)-2-phenylethyl]diphenylsilane 
• 727726-29-6 [(2S)-2-methyl-3-(phenylmethoxy)-1-propyl][2-(phenylmethyl)-1,3-dithian-2-yl]diphenylsilane 
• 727726-32-1 [(2S)-2-methyl-3-hydroxy-1-propyl][(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilane 
• 727726-39-8 [(2S)-2-methyl-3-(phenylmethoxy)-1-propyl][2-phenyl-1-oxoethyl]diphenylsilane 
• 727726-41-2 [(2S)-2-methyl-3-(phenylmethoxy)-1-propyl][2-phenyl-1-hydroxyethyl]diphenylsilane 
• 727726-30-9 [2-(phenylmethyl)-1,3-dithian-2-yl]fluorodiphenylsilane 
• 31593-52-9 2-benzyl-1,3-dithiane 

Downstream Products

• 727726-28-5 (S)-1-{(S)-3-[((R)-1-benzamido-2-phenylethyl)difluoro sily-l]-2-methylpropanoyl}pyrrolidine-2-carboxylic acid 

Relevant articles and documents

An effective total synthesis of four angiotensin-converting enzymes containing silanediols

Four angiotensin-converting enzymes (ACE) containing silanediols 1 have been synthesized successfully in 8% overall yield in 8 steps from inexpensive starting materials such as diphenyldichlorosilane 5, β-methylallylic alcohol 7 and Ellman sulfinimine 9.

Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors

Four diastereomers of a Phe-Ala peptide mimic incorporating a central silanediol group have been individually prepared and tested as inhibitors of angiotensin-converting enzyme (ACE). Three of the silanediols exhibit levels of inhibition that are similar