729-01-1 Usage
Description
4'-Nitro-3-biphenylcarboxylic acid is a chemical compound with the molecular formula C13H9NO4. It is a derivative of biphenyl and carboxylic acid, featuring a nitro group attached to the 4' position of the biphenyl ring. 4'-Nitro-3-biphenylcarboxylic acid is known for its role in the synthesis of other organic compounds and pharmaceutical products, as well as its potential applications as a detection agent for alkali and alkaline earth metal ions. Furthermore, it has been studied for its potential use in the design of new materials and as a catalyst in organic reactions, making it a compound of interest in the fields of chemistry and materials science.
Uses
Used in Pharmaceutical Synthesis:
4'-Nitro-3-biphenylcarboxylic acid is used as a key intermediate in the synthesis of various pharmaceutical products. Its unique structure allows it to be a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
As a derivative of biphenyl and carboxylic acid, 4'-Nitro-3-biphenylcarboxylic acid is utilized as a starting material or intermediate in the synthesis of a wide range of organic compounds. Its versatility in chemical reactions makes it a useful component in the creation of complex organic molecules.
Used as a Detection Agent:
4'-Nitro-3-biphenylcarboxylic acid is used as a detection agent for alkali and alkaline earth metal ions. Its chemical properties enable it to selectively interact with these metal ions, making it a valuable tool in analytical chemistry for the identification and quantification of these elements.
Used in Material Science:
4'-Nitro-3-biphenylcarboxylic acid has been studied for its potential use in the design of new materials. Its unique structure and properties may contribute to the development of advanced materials with specific characteristics for various applications in industries such as electronics, aerospace, and automotive.
Used as a Catalyst in Organic Reactions:
4'-Nitro-3-biphenylcarboxylic acid has been investigated for its potential use as a catalyst in organic reactions. Its ability to facilitate chemical transformations can improve the efficiency and selectivity of various organic synthesis processes, making it a valuable asset in the field of catalysis.
Check Digit Verification of cas no
The CAS Registry Mumber 729-01-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,2 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 729-01:
(5*7)+(4*2)+(3*9)+(2*0)+(1*1)=71
71 % 10 = 1
So 729-01-1 is a valid CAS Registry Number.
729-01-1Relevant articles and documents
Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents
Chiarelli, Laurent R.,Mori, Matteo,Barlocco, Daniela,Beretta, Giangiacomo,Gelain, Arianna,Pini, Elena,Porcino, Marianna,Mori, Giorgia,Stelitano, Giovanni,Costantino, Luca,Lapillo, Margherita,Bonanni, Davide,Poli, Giulio,Tuccinardi, Tiziano,Villa, Stefania,Meneghetti, Fiorella
supporting information, p. 754 - 763 (2018/06/26)
We report on the virtual screening, synthesis, and biological evaluation of new furan derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI). A receptor-based virtual screening procedure was applied to screen the Enamine database, identifying two compounds, I and III, endowed with a good enzyme inhibitory activity. Considering the most active compound I as starting point for the development of novel MbtI inhibitors, we obtained new derivatives based on the furan scaffold. Among the SAR performed on this class, compound 1a emerged as the most potent MbtI inhibitor reported to date (Ki = 5.3 μM). Moreover, compound 1a showed a promising antimycobacterial activity (MIC99 = 156 μM), which is conceivably related to mycobactin biosynthesis inhibition.
Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)
Venkatraj, Muthusamy,Messagie, Jonas,Joossens, Jurgen,Lambeir, Anne-Marie,Haemers, Achiel,Van Der Veken, Pieter,Augustyns, Koen
supporting information; experimental part, p. 1557 - 1568 (2012/04/17)
Recent drug discovery programs targeting urokinase plasminogen activator (uPA) have resulted in nonpeptidic inhibitors consisting of amidine or guanidine functional groups attached to aromatic or heteroaromatic scaffolds. There is a general problem of poor oral bioavailability of these charged inhibitors. In this paper, we report the synthesis and evaluation of a series of naphthamide and naphthalene sulfonamides as uPA inhibitors containing non-basic groups as substitute for amidine or guanidine groups.
AMINO ACIDS
-
Page/Page column 48, (2008/06/13)
Compounds of formula (I): Z’ -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z’ is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.
