73035-16-2

Basic information

• Product Name: 3-ACETYLBENZENESULFONYL CHLORIDE
• Synonyms: AKOS BB-9466;3-ACETYLBENZENESULFONYL CHLORIDE;Benzenesulfonyl chloride, 3-acetyl- (9CI);3-Acetylbenzenesulfonyl chloride, GC 97%
• CAS NO: 73035-16-2
• Molecular Formula: C₈H₇ClO₃S
• Molecular Weight: 218.66
• Product Categories: SULFONYLHALIDE
• Mol File: 73035-16-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 43-45°C
• Boiling Point: 347 °C at 760 mmHg
• Flash Point: 163.7 °C
• Appearance: /
• Density: 1.387g/cm³
• Vapor Pressure: 5.54E-05mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 3-ACETYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETYLBENZENESULFONYL CHLORIDE(73035-16-2)
• EPA Substance Registry System: 3-ACETYLBENZENESULFONYL CHLORIDE(73035-16-2)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 73035-16-2(Hazardous Substances Data)

Usage

Description

3-ACETYLBENZENESULFONYL CHLORIDE is an organic chemical compound with the molecular formula C8H7ClO3S. It is a derivative of benzene, featuring a sulfonyl chloride group attached to the 3-position, and an acetyl group at the 4-position. 3-ACETYLBENZENESULFONYL CHLORIDE is a versatile intermediate in organic synthesis and can be used in the preparation of various pharmaceuticals, agrochemicals, and other specialty chemicals.

Uses

Used in Pharmaceutical Industry:
3-ACETYLBENZENESULFONYL CHLORIDE is used as a key intermediate in the synthesis of various pharmaceutical compounds. It serves as a starting material for the preparation of 4-ethylsulfonyl-α-bromoacetophenone, which is then subjected to classical acetamidomalonate addition/decarboxylative hydrolysis to generate the amino acidic moiety. This process is crucial for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
3-ACETYLBENZENESULFONYL CHLORIDE is also utilized as a building block in the synthesis of agrochemicals, such as insecticides, herbicides, and fungicides. Its unique chemical structure allows for the creation of novel compounds with improved efficacy and selectivity in controlling pests and diseases in agriculture.
Used in Specialty Chemicals:
In addition to its applications in pharmaceuticals and agrochemicals, 3-ACETYLBENZENESULFONYL CHLORIDE is employed in the synthesis of specialty chemicals, such as dyes, pigments, and polymers. Its reactivity and functional groups enable the development of innovative materials with unique properties and applications in various industries.

InChI:InChI=1/C8H7ClO3S/c1-6(10)7-3-2-4-8(5-7)13(9,11)12/h2-5H,1H3

Upstream product

• 99-03-6 1-(3-aminophenyl)ethanone 

Downstream Products

• 111711-76-3 1-(3-Acetyl-benzenesulfonyl)-5-ethoxy-pyrrolidin-2-one 
• 74529-64-9 3-(3-Acetyl-benzenesulfonyl)-5,5-diphenyl-oxazolidine-2,4-dione 
• 881676-84-2 1-[(3-acetylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde 
• 173158-15-1 3-acetyl-N,N-dimethylbenzenesulfonamide 
• 173158-12-8 N-methyl-3-acetylbenzenesulfonamide 
• 1186422-04-7 3-acetyl-N-[2-(dimethylamino)ethyl]-N-methylbenzenesulfonamide 
• 1186421-63-5 N,N-dimethyl-3-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)benzenesulfonamide 
• 1186421-69-1 3-[3-(7-methoxy-1H-indazol-4-yl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide 
• 1186421-60-2 3-(3-(1H-indol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethylbenzenesulfonamide 
• 1186421-66-8 3-(3-(1H-indol-6-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide 
• 1186421-53-3 3-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-n,n-dimethylbenzenesulfonamide 
• 1186421-45-3 3-(3-(3-hydroxyphenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-N-methylbenzenesulfonamide 
• 1186421-43-1 3-[3-(3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide 
• 1186422-01-4 3-(3-iodo-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethylbenzenesulfonamide 

Relevant articles and documents

4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

4-phenyl-N-(phenyl)thiazol-2-amine and 4-(pyridin-3-yl)-N-( phenyl) thiazol-2-amine derivatives and the corresponding thiadiazole, thiophene, oxazole, oxadiazole, imidazole and triazole derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders.

Dihydrothiazolone compounds containing sulfamide and pharmaceutical compositions and use thereof

The invention provides dihydrothiazolone compounds containing sulfamide, represented by a formula (I), pharmaceutical compositions and use thereof. The compounds can be combined with proteins with bromodomain structural domains so as to adjust a downstream signal channel and exert a special function, and can be used for treating many diseases associated with bromodomain structural domains. The compounds can interfere combination of Brd4 with the bromodomain structural domain and an acetylized histone so as to down-regulate transcription of a cancer gene c-myc and associated target genes thereof, so that the compounds can become effective therapeutic drugs for treating tumors.