73234-94-3

Basic information

• Product Name: Benzene, 1-methoxy-2-(1,2-propadienyl)-
• CAS NO: 73234-94-3
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• Mol File: 73234-94-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-2-(1,2-propadienyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-2-(1,2-propadienyl)-(73234-94-3)
• EPA Substance Registry System: Benzene, 1-methoxy-2-(1,2-propadienyl)-(73234-94-3)

Safety Data

• Hazardous Substances Data: 73234-94-3(Hazardous Substances Data)

Upstream product

• 578-57-4 2-bromoanisole 
• 135-02-4 ortho-anisaldehyde 
• 19350-70-0 2-methoxybenzaldehyde p-toluenesulfonylhydrazone 
• 74-86-2 acetylene 
• 50-00-0 formaldehyd 
• 767-91-9 1-ethynyl-2-methoxybenzene 
• 132608-15-2 1-(2,2-dibromocyclopropyl)-2-methoxybenzene 
• 7342-00-9 3-(2-methoxyphenyl)prop-2-ynoic acid 
• 106-96-7 propargyl bromide 
• 529-28-2 4-iodoanisol 
• 1421710-47-5 1-(3-iodoprop-1-ynyl)-2-methoxybenzene 
• 154884-62-5 3-(2-methoxyphenyl)propargyl alcohol 
• 16750-63-3 2-methoxyphenylmagnesium bromide 
• 146432-19-1 B-allenyl-9-BBN 

Downstream Products

• 1338461-16-7 C₁₇H₁₈O₂ 
• 1338461-20-3 C₂₄H₂₄O₃ 
• 1338461-18-9 C₂₄H₂₄O₃ 

Relevant articles and documents

Preparation of (E)-1,3-Enyne Derivatives through Palladium Catalyzed Hydroalkynylation of Allenes

A general and efficient palladium catalyzed hydroalkynylation of allenes was developed to produce synthetically versatile (E)-1,3-enyne derivatives with high regio- and stereoselectivity. This catalytic system proceeded under mild conditions and was compatible with a broad range of substrates, especially for allenes without electron-bias groups. This work further broadens the synthetic potential of these scaffolds in organic synthesis and medicinal chemistry.

Trifluoromethylation of Allenes: An Expedient Access to α-Trifluoromethylated Enones at Room Temperature

A silver(I) catalyzed regioselective trifluoromethylation of allenes using Langlois's salt (NaOSOCF3) is demonstrated. This transformation enables direct expedient access to α-trifluoromethylated acroleins, which are valuable synthons for a number of pharmaceuticals and agrochemicals containing vinyl-CF3 moieties. Versatility of this trifluoromethylation method has been established with good yield and excellent regioselectivity. Preliminary experiments and computational studies were carried out to elucidate the mechanistic insight of this protocol.

Fluorinative Rearrangements of Substituted Phenylallenes Mediated by (Difluoroiodo)toluene: Synthesis of α-(Difluoromethyl)styrenes

Phenylallenes undergo fluorinative rearrangement upon the action of (difluoroiodo)toluene in the presence of 20 mol % BF3?OEt2 to yield α-difluoromethyl styrenes. This unprecedented reaction was entirely chemoselective for the internal allene π bond, and showed remarkable regioselectivity during the fluorination event. Substituted phenylallenes, phenylallenes possessing both phenyl- and α-allenyl substituents, and diphenylallenes were investigated, and good functional-group compatibility was observed throughout. The ease with which allenes can be prepared on a large scale, and the operational simplicity of this reaction allowed us to rapidly access fluorine-containing building blocks that have not been accessed by conventional deoxyfluorination strategies.