73838-85-4

Basic information

• Product Name: α-methyl-(E)-3,4-dehydroglutamic acid
• Synonyms: α-methyl-(E)-3,4-dehydroglutamic acid
• CAS NO: 73838-85-4
• Molecular Weight: 159.142
• Mol File: 73838-85-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: α-methyl-(E)-3,4-dehydroglutamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-methyl-(E)-3,4-dehydroglutamic acid(73838-85-4)
• EPA Substance Registry System: α-methyl-(E)-3,4-dehydroglutamic acid(73838-85-4)

Safety Data

• Hazardous Substances Data: 73838-85-4(Hazardous Substances Data)

Upstream product

• 73838-90-1 Dimethyl (E)-2-(benzylideneamino)-2-methylpent-3-ene-2,5-dioate 
• 101220-14-8 2-Methyl-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid ethyl ester 
• 170943-51-8 diethyl α-methyl-(E)-3,4-dehydroglutamate 

Downstream Products

• 71-90-9 2-methylglutamic acid 

Relevant articles and documents

First Michael addition reaction of α-substituted N-diphenylmethyleneglycinate with ethyl propiolate. Synthesis of α-substituted (E)-3,4-dehydroglutamic acids

(E)-α-substituted 3,4-dehydro glutamic acids 4, were prepared from ethyl N-diphenylmethyleneglycinate 5 by alkylation with a suitable alkyl halide followed by a Michael type addition reaction with ethyl propiolate, giving rise to a mixture of E/Z adducts 7/8. Sequential hydrolysis of the substituted glycine synthons 7/8 afforded the titled compounds 4 as single diastereomers.