73842-46-3

Basic information

• Product Name: 4-chloro-N-(4-methylbenzyl)aniline
• CAS NO: 73842-46-3
• Molecular Formula: C₁₄H₁₄ClN
• Molecular Weight: 231.7207
• Mol File: 73842-46-3.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 368.3°C at 760 mmHg
• Flash Point: 176.5°C
• Density: 1.171g/cm³
• Vapor Pressure: 1.29E-05mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 4-chloro-N-(4-methylbenzyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(4-methylbenzyl)aniline(73842-46-3)
• EPA Substance Registry System: 4-chloro-N-(4-methylbenzyl)aniline(73842-46-3)

Safety Data

• Hazardous Substances Data: 73842-46-3(Hazardous Substances Data)

Upstream product

• 80-38-6 fenson 
• 104-84-7 para-methylbenzylamine 
• 80-33-1 chlorofensone 
• 128886-84-0 p-Chlorophenyl p-nitrobenzenesulphonate 
• 33667-89-9 N-(4-chlorophenyl)-4-methylbenzamide 
• 106-47-8 4-chloro-aniline 
• 100-00-5 4-chlorobenzonitrile 
• 589-18-4 4-Methylbenzyl alcohol 
• 29574-09-2 p-chloro-N-(p-methylbenzylidene)aniline 
• 599-89-3 4-chlorophenyl p-toluenesulfonate 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 1422969-35-4 N¹,N⁴-bis(4-chlorophenyl)-N¹,N⁴-bis(4-methylbenzyl)fumaramide 

Relevant articles and documents

Enhanced Hydride Donation Achieved Molybdenum Catalyzed Direct N-Alkylation of Anilines or Nitroarenes with Alcohols: From Computational Design to Experiment

An example of homogeneous Mo-catalyzed direct N-alkylation of anilines or nitroarenes with alcohols is presented. The DFT aimed design suggested the easily accessible bis-NHC-Mo(0) complex features a strong hydride-donating ability, achieving effective N-alkylation of anilines or challenging nitroarenes with alcohols. The enhanced hydride-donating strategy should be useful in designing highly active systems for borrowing hydrogen transformations.

A microwave-assisted SmI2-catalyzed direct N-alkylation of anilines with alcohols

A new protocol for the alkylation of aromatic amines has been described using alcohols in the presence of SmI2 as a catalyst with the generation of water as the sole byproduct. The reaction proceeds under MW conditions and selectively generates monoalkylated amines. This protocol features a broad substrate scope and good functional-group tolerance with moderate to high yields.

An Efficient Metal-Free Method for the Denitrosation of Aryl N-Nitrosamines at Room Temperature

A simple and practical method for the denitrosation of aryl N-nitrosamines to secondary amines is reported under metal-free conditions using iodine and triethylsilane. Several reduction-susceptible functional groups such as alkene, alkyne, nitrile, nitro, aldehyde, ketone and ester were found to be very stable during the denitrosation, which is remarkable. Broad substrate scope, room temperature reactions and excellent yields are the additional features of the current methodology. (Figure presented.).