7403-46-5 Usage
Description
2-Chloro-1-methylpyridinium p-Toluenosulfonate, also known as 2-chloro-1-methylpyridinium p-toluenesulfonate, is a chemical compound that serves as a dehydrating agent in various chemical reactions. It is characterized by its ability to facilitate the conversion of carboxylic acids and imines into their corresponding products, making it a valuable component in synthetic chemistry.
Uses
Used in Organic Synthesis:
2-Chloro-1-methylpyridinium p-Toluenosulfonate is used as a dehydrating agent for the Staudinger-type reaction of carboxylic acids with imines. This reaction is crucial in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. 2-CHLORO-1-METHYLPYRIDINIUM P-TOLUENESULFONATE's dehydrating properties enable the formation of the desired products by promoting the reaction between carboxylic acids and imines, leading to the formation of amines and esters.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-chloro-1-methylpyridinium p-Toluenosulfonate is used as a key intermediate in the synthesis of various drugs and drug candidates. Its ability to facilitate the Staudinger-type reaction allows for the efficient production of complex molecular structures, which are often required in the development of new medications.
Used in Research and Development:
2-Chloro-1-methylpyridinium p-Toluenosulfonate is also utilized in research and development laboratories, where it is employed to study the mechanisms of various chemical reactions and to develop new synthetic methodologies. Its dehydrating properties make it a valuable tool for chemists working on the design and synthesis of novel compounds with potential applications in various fields, including materials science, biology, and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 7403-46-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,0 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 7403-46:
(6*7)+(5*4)+(4*0)+(3*3)+(2*4)+(1*6)=85
85 % 10 = 5
So 7403-46-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8O3S.C6H7ClN/c1-6-2-4-7(5-3-6)11(8,9)10;1-8-5-3-2-4-6(8)7/h2-5H,1H3,(H,8,9,10);2-5H,1H3/q;+1
7403-46-5Relevant articles and documents
Asymmetric syntheses of a GPR40 receptor agonist via diastereoselective and enantioselective conjugate alkynylation
Woo, Jacqueline C.S.,Cui, Sheng,Walker, Shawn D.,Faul, Margaret M.
experimental part, p. 4730 - 4737 (2010/08/06)
Two asymmetric methods to synthesize a potent GPR40 receptor agonist are reported. Both synthetic routes utilize readily available, inexpensive starting materials and reagents. The first route relies on a highly diastereoselective conjugate alkynylation of an ephedrine-derived oxazepanedione acceptor. The second route features the enantioselective alkynylation of a Meldrum's acid-derived acceptor mediated by a chiral zinc cinchonidine reagent.
Pseudo Vilsmeier reagents a new protocol for regiospecific C-C bond formation in pyridines
Yu, Chu-Yi,Taylor, David L.,Meth-Cohn, Otto
, p. 6661 - 6664 (2007/10/03)
2-Fluoro- and 2,6-difluoropyridine are readily quaternised with methyl p-toluenesulfonate and methyl triflate respectively. These salts readily undergo substitution of fluorine by enamines, the difluoro-derivatives being capable of specific mono- or disubstitution in a symmetrical or unsymmetrical manner. The products reduced to give keto-1, 2, 3, 6-tetrahydropyridines, can be hydrosed to the corresponding ketopyridines or hydrogenated to give ketopiperidines.