74175-13-6 Usage
Description
4-[(3-chloropropanoyl)amino]phenylarsonic acid is a chemical compound derived from arsenic, featuring a phenyl group with an attached amino group and a chloropropanoyl group. 4-[(3-chloropropanoyl)amino]phenylarsonic acid is known for its herbicidal properties and is utilized in agriculture for controlling broadleaf weeds.
Uses
Used in Agricultural Industry:
4-[(3-chloropropanoyl)amino]phenylarsonic acid is used as a post-emergent herbicide for controlling broadleaf weeds in various crops. It functions by inhibiting the enzyme acetohydroxyacid synthase (AHAS), which plays a crucial role in the biosynthesis of branched-chain amino acids in plants. The disruption of this enzyme leads to the impaired growth and eventual death of the affected plants.
However, it is essential to handle and use 4-[(3-chloropropanoyl)amino]phenylarsonic acid with caution due to its toxicity to humans and animals. Additionally, proper management is required to minimize potential environmental risks associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 74175-13-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,1,7 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 74175-13:
(7*7)+(6*4)+(5*1)+(4*7)+(3*5)+(2*1)+(1*3)=126
126 % 10 = 6
So 74175-13-6 is a valid CAS Registry Number.
74175-13-6Relevant articles and documents
Dual Inhibition of Pyruvate Dehydrogenase Complex and Respiratory Chain Complex Induces Apoptosis by a Mitochondria-Targeted Fluorescent Organic Arsenical in vitro and in vivo
Fan, Xiao-Yang,Hu, Yan-Jun,Jiang, Feng-Lei,Liu, Yi,Liu, Yu-Jiao,Xia, Yin-Zheng,Zhang, Dong-Dong,Zhou, Fu-Ling
, (2020)
Based on the potential therapeutic value in targeting mitochondria and the fluorophore tracing ability, a fluorescent mitochondria-targeted organic arsenical PDT-PAO-F16 was fabricated, which not only visualized the cellular distribution, but also exerted anti-cancer activity in vitro and in vivo via targeting pyruvate dehydrogenase complex (PDHC) and respiratory chain complexes in mitochondria. In details, PDT-PAO-F16 mainly accumulated into mitochondria within hours and suppressed the activity of PDHC resulting in the inhibition of ATP synthesis and thermogenesis disorder. Moreover, the suppression of respiratory chain complex I and IV accelerated the mitochondrial dysfunction leading to caspase family-dependent apoptosis. In vivo, the acute promyelocytic leukemia was greatly alleviated in the PDT-PAO-F16 treated group in APL mice model. Our results demonstrated the organic arsenical precursor with fluorescence imaging and target-anticancer efficacy is a promising anticancer drug.
