7483-59-2

Basic information

• Product Name: 3-(1-Piperazinyl)-1,2-propanediol
• Synonyms: 3-(1-Piperazinyl)-1,2-propanediol;3-(piperazin-1-yl)propane-1,2-diol;N-(2,3-Dihydroxypropyl)piperazine
• CAS NO: 7483-59-2
• Molecular Formula: C₇H₁₆N₂O₂
• Molecular Weight: 160.21414
• EINECS: 231-288-8
• Product Categories: pharmacetical
• Mol File: 7483-59-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 304.8°C at 760 mmHg
• Flash Point: 138.1°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 8.08E-05mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: 3-(1-Piperazinyl)-1,2-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-Piperazinyl)-1,2-propanediol(7483-59-2)
• EPA Substance Registry System: 3-(1-Piperazinyl)-1,2-propanediol(7483-59-2)

Safety Data

• Hazardous Substances Data: 7483-59-2(Hazardous Substances Data)

Usage

General Description

3-(1-Piperazinyl)-1,2-propanediol is a chemical compound that consists of a piperazine ring and a propanediol group. It is commonly used as a pharmaceutical intermediate in the synthesis of various drugs, including antipsychotic and antidepressant medications. The compound is known for its ability to enhance the solubility and absorption of certain drugs in the body, making it an important ingredient in pharmaceutical formulations. Additionally, it has been studied for its potential use in the treatment of various medical conditions, including anxiety disorders and irritable bowel syndrome. Its unique structure and properties make it a valuable component in pharmaceutical research and development.

InChI:InChI=1/C7H16N2O2/c10-6-7(11)5-9-3-1-8-2-4-9/h7-8,10-11H,1-6H2

Upstream product

• 110-85-0 piperazine 
• 96-24-2 3-monochloro-1,2-propanediol 
• 56-81-5 glycerol 
• 556-52-5 oxiranyl-methanol 

Downstream Products

• 110-85-0 piperazine 
• 76950-43-1 2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 80273-37-6 3-{4-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-propane-1,2-diol 

Relevant articles and documents

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METHOD FOR PRODUCING HYDROXYALKYLTRIETHYLENEDIAMINE HAVING IMPROVED HUE

PROBLEM TO BE SOLVED: To provide a production method which makes it possible to improve the hue of a cyclic alkanolamine such as a hydroxyalkyltriethylenediamine and efficiently obtain a high-purity bicyclic compound. SOLUTION: A method for producing the bicyclic diamine includes bringing a crude hydroxyalkyltriethylenediamine reaction liquid comprising a hydroxyalkyltriethylenediamine represented by formula (1) into contact with oxygen at 110-170°C and then distilling and purifying it (R1-R10 independently represent H, a C1-4 alkyl group or a C1-4 hydroxyalkyl group). SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

METHOD FOR PRODUCING N-MONOSUBSTITUTED PIPERAZINE

PROBLEM TO BE SOLVED: To provide a method for producing N-monosubstituted piperazine selectively with high productivity and high yields. SOLUTION: An electrophilic reagent and an alkali source are added to a solution comprising piperazine, which has been heated at 70-90°C, to make a reaction occur therebetween, so that an addition ratio of the electrophilic reagent to the piperazine is 0.2-0.7 mole and an addition amount rate of the electrophilic reagent exceeds an addition amount rate of the alkali source. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT