751-97-3 Usage
Description
ROLITETRACYCLINE, also known as N-(pyrrolidinomethyl)tetracycline or Syntetrin, is a semi-synthetic tetracycline antibiotic derivative that was introduced in the late 1950s. It is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline, resulting in a pro-drug of tetracycline with improved bioavailability. ROLITETRACYCLINE is characterized by its broad-spectrum Gram-positive activity in vivo, although its pH instability limits its use to parenteral administration. It is very soluble in water and provides a means of injecting the antibiotic in a small volume of solution.
Uses
Used in Pharmaceutical Industry:
ROLITETRACYCLINE is used as an antibiotic for the treatment of serious bacterial infections when oral administration is not practicable. It is administered intravenously or intramuscularly to provide effective treatment in such cases.
ROLITETRACYCLINE is used as a pro-drug for improving the bioavailability of tetracycline. The pyrrolidine moiety in ROLITETRACYCLINE enhances its solubility and absorption compared to the parent compound, tetracycline.
ROLITETRACYCLINE is used as a broad-spectrum antibiotic with Gram-positive activity, providing in vivo efficacy against a range of bacterial infections.
However, it is important to note that ROLITETRACYCLINE is no longer widely used due to its limitations, such as pH instability and the lack of extensive investigation into its intrinsic in vitro activity and structure-activity relationships for the tetracycline molecule.
Pharmaceutical Applications
2-N-pyrrolidinomethyl-tetracycline. A semisynthetic derivative
of tetracycline supplied as the nitrate sesquihydrate for
parenteral use.
It is not absorbed from the gastrointestinal tract. It is highly
soluble and therefore can be administered parenterally. Peak
plasma concentrations of 4–6 mg/L occur at 0.5–1 h after
350 mg intravenously. The plasma elimination half-life is 5–8 h.
About 50% of the dose is excreted in the urine, producing
high concentrations.
Intravenous administration is occasionally accompanied by
abnormal taste, shivering and rigors, hot flushes, facial reddening,
dizziness and, rarely, circulatory collapse. Symptoms
of myasthenia gravis have occasionally been exacerbated.
Check Digit Verification of cas no
The CAS Registry Mumber 751-97-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,5 and 1 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 751-97:
(5*7)+(4*5)+(3*1)+(2*9)+(1*7)=83
83 % 10 = 3
So 751-97-3 is a valid CAS Registry Number.
InChI:InChI=1/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)
