754206-43-4

Basic information

• Product Name: (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine
• Synonyms: (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine
• CAS NO: 754206-43-4
• Molecular Weight: 377.48
• Mol File: 754206-43-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine(754206-43-4)
• EPA Substance Registry System: (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-{[(methylsulfonyl)oxy]methyl}piperidine(754206-43-4)

Safety Data

• Hazardous Substances Data: 754206-43-4(Hazardous Substances Data)

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 201855-64-3 (3R,4R)-1-benzyl-4-(4-fluorophenyl)-3-(hydroxymethyl)piperidine 

Downstream Products

• 110429-35-1 (-)-paroxetine hydrochloride 

Relevant articles and documents

A convenient synthesis of (-)-paroxetine

A convenient synthesis of the antidepressant paroxetine starting from 1-benzyl-4-piperidone (2) is reported. A stereoselective reduction resulted in cis-piperidine-3-methanol [(+)-6]. The reaction between cis-piperidine-3- methanol mesylate (7) and sesamol led to benzyl-protected trans-paroxetine (9) through an inversion reaction of the stereogenic center at position 3. The latter compound was deprotected by hydrogenolysis. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.