754240-09-0 Usage
Description
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride is a complex organic compound with a unique molecular structure that features a quinolin-4-ylthio group, a pentyloxy chain, and a morpholinomethyl group attached to a 4H-pyran-4-one core. 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride is characterized by its potential biological activity and its ability to interact with specific molecular targets.
Used in Pharmaceutical Industry:
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride is used as a Rac family GTPase inhibitor for its ability to modulate the activity of the Rac subfamily of Rho GTPases, which are important regulators of cellular processes such as actin cytoskeleton remodeling, cell migration, and transformation.
Used in Alzheimer's Disease Research:
In the context of Alzheimer's disease research, this compound is used to inhibit APP processing by γ-secretase, leading to a reduction in the accumulation of Aβ40 and Aβ42 peptides, which are implicated in the pathogenesis of the disease.
Used in Cancer Research:
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride is used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity, which is relevant to the understanding of Wnt signaling pathways and their role in cancer development and progression.
Used in Neuroscience Research:
5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride is also used in neuroscience research to investigate the effects of Rac1 activity on the morphology of dendritic spines in hippocampal neurons, as it has been shown to increase the size but decrease the density of dendritic spines at certain concentrations, which could have implications for understanding the role of Rac1 in synaptic plasticity and related neurological disorders.
Biological Activity
Inhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (K D values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β -amyloid peptide production in vivo .
Biochem/physiol Actions
EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.
references
[1] shutes a, onesto c, picard v, et al. specificity and mechanism of action of eht 1864, a novel small molecule inhibitor of rac family small gtpases. journal of biological chemistry, 2007, 282(49): 35666-35678.
Check Digit Verification of cas no
The CAS Registry Mumber 754240-09-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,4,2,4 and 0 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 754240-09:
(8*7)+(7*5)+(6*4)+(5*2)+(4*4)+(3*0)+(2*0)+(1*9)=150
150 % 10 = 0
So 754240-09-0 is a valid CAS Registry Number.
