75510-02-0

Basic information

• Product Name: 6-benzyl-7,8-dihydro-5H-1,6-naphthyridine
• Synonyms: 6-benzyl-7,8-dihydro-5H-1,6-naphthyridine;6-benzyl-5,6,7,8-tetrahydro-1,6-naphthyridine
• CAS NO: 75510-02-0
• Molecular Formula: C₁₅H₁₆N₂
• Molecular Weight: 224.3009
• Mol File: 75510-02-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 343.5°Cat760mmHg
• Flash Point: 161.5°C
• Appearance: /
• Density: 1.127g/cm³
• Vapor Pressure: 7.02E-05mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 6-benzyl-7,8-dihydro-5H-1,6-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-7,8-dihydro-5H-1,6-naphthyridine(75510-02-0)
• EPA Substance Registry System: 6-benzyl-7,8-dihydro-5H-1,6-naphthyridine(75510-02-0)

Safety Data

• Hazardous Substances Data: 75510-02-0(Hazardous Substances Data)

Usage

General Description

6-benzyl-7,8-dihydro-5H-1,6-naphthyridine is a chemical compound that belongs to the class of naphthyridine derivatives. It is a bicyclic heterocyclic compound with a benzyl group attached to one of the nitrogen atoms. 6-benzyl-7,8-dihydro-5H-1,6-naphthyridine has potential pharmaceutical applications due to its ability to modulate a variety of biological targets. It has been studied for its potential as an anti-cancer and anti-inflammatory agent, as well as for its inhibitory activity against certain enzymes. Overall, 6-benzyl-7,8-dihydro-5H-1,6-naphthyridine shows promise as a versatile and potentially valuable chemical compound in various fields of research and application.

InChI:InChI=1/C15H16N2/c1-2-5-13(6-3-1)11-17-10-8-15-14(12-17)7-4-9-16-15/h1-7,9H,8,10-12H2

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 25186-34-9 3-aminoprop-2-enal 
• 253-72-5 1,6-naphthyridine 
• 100-39-0 benzyl bromide 
• 107-02-8 acrolein 
• 2450-71-7 Propargylamine 
• 90781-10-5 6-Benzyl-[1,6]naphthyridin-6-ium 
• 76063-24-6 β-aminoacrolein 

Downstream Products

• 80957-68-2 5,6,7,8-tetrahydro-1,6-naphthyridine 
• 83082-13-7 8-methyl-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 259809-49-9 6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-2-carboxylic acid 
• 259809-47-7 6-(tert-butoxycarbonyl)-2-methoxycarbonyl-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 259809-46-6 6-(tert-butoxycarbonyl)-2-cyano-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 259809-44-4 7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester 

Relevant articles and documents

Application of Cu-MOF (Metal Organic Framework) type catalyst in preparing polysubstitution pyridine derivative

The invention discloses application of Cu-MOF (Metal Organic Framework) type catalyst in preparing polysubstitution pyridine derivative. The method for carrying out catalytic preparation on the polysubstitution pyridine derivative by the Cu-MOF type catalyst comprises the following steps: carrying out cyclization reaction on an even mixing system which contains the Cu-MOF type catalyst, carbonyl compound, propargylamine and solvent at the temperature of room temperature to 100 DEG C to obtain the polysubstitution pyridine derivative. According to the method, the amination/cyclization/arylatingreaction of the catalyzing carbonylation compound of the Cu-MOF type catalyst and propargylamine can be realized for the first time, and various polysubstitution pyridine derivatives can be obtainedat a high yield. The Cu-MOF type catalyst used by the invention is heterogeneous catalyst which is stable for air and water, environment pollution is reduced, the Cu-MOF type catalyst does not need tobe protected by inert gas, a synthesis method is simple, raw material price is low, and the Cu-MOF type catalyst can be reused. Meanwhile, the Cu-MOF type catalyst has the advantages of low reactiontemperature, high reaction selectivity, high efficiency and wide applicable range of substrate.

SUBSTITUTE 1, 6-NAPHTHYRIDINES FOR USE AS SCD INHIBITORS

The present invention relates to substituted tetrahydronaphthyridine (THN) compounds of the formula (I) and salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for inhibiting SCD activity.

Sequential amination/annulation/aromatization reaction of carbonyl compounds and propargylamine: A new one-pot approach to functionalized pyridines

A general one-pot synthesis of pyridines 4a-t from the reaction of dialkyl acyclic/cyclic ketones 1a-i, methyl, aryl/heteroaryl ketones 1m-r, and aldehydes bearing α-hydrogens 1s,t with propargylamine 2 is described. Gold and copper salts are efficient catalysts for the reaction of ketones with 2. The formation of the pyridines 4 is suggested to proceed through the sequential amination of carbonyl compounds followed by regioselective 6-endo-dig cyclization of the N-propargylenamine (N-propargyldienamine) intermediate 3(5) and aromatization reaction. Whereas the preparation of linear polycyclic pyridine 4i can be carried out by reacting cholestan-3-one 1i with 2, the angular polycyclic pyridine 4j has been obtained starting from cholest-5-en-3-one 1j. Selectivity of the reaction of polycyclic dicarbonyls 1k,1 with 2 has also been investigated.