755752-82-0

Basic information

• Product Name: 1H-INDAZOLE-7-CARBOXYLIC ACID
• Synonyms: 7-INDAZOLE CARBOXYLLIC ACID;Methyl indazole-7-carboxylate;1H-Indazole-7-carboxylic acid methyl ester;Methyl indazole-7-carboxy...;7-(Methoxycarbonyl)-1H-indazole;7-(1H)Indazole carboxylic acid Methyl ester
• CAS NO: 755752-82-0
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Product Categories: Indazoles
• Mol File: 755752-82-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 345.2 °C at 760 mmHg
• Flash Point: 162.6 °C
• Appearance: /
• Density: 1.324
• Vapor Pressure: 6.24E-05mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.93±0.40(Predicted)
• CAS DataBase Reference: 1H-INDAZOLE-7-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDAZOLE-7-CARBOXYLIC ACID(755752-82-0)
• EPA Substance Registry System: 1H-INDAZOLE-7-CARBOXYLIC ACID(755752-82-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 755752-82-0(Hazardous Substances Data)

Usage

General Description

1H-Indazole-7-carboxylic acid is a chemical compound with the molecular formula C9H6N2O2. It is a carboxylic acid derivative of indazole, a heterocyclic compound with a bicyclic structure. 1H-Indazole-7-carboxylic acid has potential pharmaceutical applications, particularly in the field of medicinal chemistry. It is used as a starting material in the synthesis of various bioactive molecules, including potential drug candidates and pharmacological tools. Its unique structure and properties make it a valuable building block for the development of new drug compounds. Additionally, 1H-Indazole-7-carboxylic acid has been studied for its anti-cancer and anti-inflammatory activities, demonstrating its potential for therapeutic applications. Overall, this compound plays an important role in the development of new pharmaceuticals and biologically active molecules.

InChI:InChI=1/C9H8N2O2/c1-13-9(12)7-4-2-3-6-5-10-11-8(6)7/h2-5H,1H3,(H,10,11)

Upstream product

• 253120-49-9 methyl 2-amino-3-formylbenzoate 
• 138229-59-1 3-formyl-2-nitrobenzoic acid methyl ester 
• 5471-82-9 methyl 3-methyl-2-nitrobenzoate 
• 1127-59-9 7-methyl-1H-indole-2,3-dione 
• 1132-03-2 2-(hydroxyimino)-N-(2-methylphenyl)acetamide 
• 95-53-4 o-toluidine 
• 37619-23-1 2-acetylamino-3-methyl-benzoic acid methyl ester 
• 22223-49-0 methyl 2-amino-3-methylbenzoate 
• 67-56-1 methanol 
• 677304-69-7 1H-indazole-7-carboxylic acid 
• 4389-45-1 3-methylantranilic acid 

Downstream Products

• 1092961-09-5 (1H-indazol-7-yl)methanol 
• 312746-72-8 1-H-indazole-7-carbaldehyde 
• 1196713-67-3 2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester 
• 944899-05-2 methyl 3-iodo-1H-indazole-7-carboxylic acid 
• 1031413-43-0 1'-(1H-indazol-7-ylcarbonyl)-6,7-dimethylspiro[chromene-2,4'-piperidin]-4(3H)-one 
• 952479-66-2 methyl 2-{4-[(dimethylamino)methyl]-phenyl}-2H-indazole-7-carboxylate 

Relevant articles and documents

Indazole ester compound and pharmaceutical application thereof

The invention provides an indazole ester compound and a pharmaceutical application thereof. Specifically provided is a compound represented by a formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or an optical isomer thereof, or an isotope substitution form thereof. The compound can be used for effectively inhibiting the activity of SARS-CoV-2Mpro, and can be used for preparing an SARS-CoV-2Mpro inhibitor. The compound provided by the invention has a good application prospect in preparation of drugs for resisting novel coronavirus and drugs for preventing and/or treating novel coronavirus pneumonia.

A novel synthetic method for preparing an anticancer medicine Niraparib

A novel synthetic method for preparing an anticancer medicine Niraparib is disclosed. The method includes subjecting an initial raw material that is 3-formyl-2-nitrobenzoic acid to 2-site nitro reduction, diazotization, reduction, cyclization, substitution, isomer resolution, amidation, and BOC removing to obtain the optically pure Niraparib the purity of which is 97.51% or above. The method is simple, convenient, high in yield, low in loss, easy to operate, low in equipment requirement and suitable for industrial production.

Asymmetric Synthesis of Fused Polycyclic Indazoles through Aminocatalyzed Aza-Michael Addition/Intramolecular Cyclization

The first example of an asymmetric aminocatalyzed aza-Michael addition of 1H-indazole derivatives to α,β-unsaturated aldehydes is described. The iminium/enamine cascade process lies at the heart of our strategy, leading to enantioenriched fused polycyclic indazole architectures. Variations on both the α,β-unsaturated aldehydes and the indazole-7-carbaldehyde heterocycles were studied in order to broaden the scope of the transformation in synthetically interesting directions. The fused polycyclic indazoles exhibit fluorescence properties and can undergo synthetic transformations.