756526-04-2 Usage
Description
Alpha-amine-omega-propionic acid octaethylene glycol, also known as Amino-PEG8-acid, is a water-soluble polyethylene glycol (PEG) linker that features an amino group (NH2) with a terminal carboxylic acid. This molecule is characterized by its reactivity with activated NHS esters, carbonyls (ketone, aldehyde), and other functional groups, making it a versatile component in various applications.
Uses
Used in Pharmaceutical Industry:
Alpha-amine-omega-propionic acid octaethylene glycol is used as a molecular linker for enhancing the solubility and stability of drug molecules. Its ability to react with various functional groups allows for the creation of prodrugs or drug conjugates with improved pharmacokinetic properties, leading to better bioavailability and reduced side effects.
Used in Bioconjugation:
In the field of bioconjugation, alpha-amine-omega-propionic acid octaethylene glycol serves as a versatile linker for attaching biologically active molecules, such as peptides, proteins, or small molecules, to other biomolecules or surfaces. This enhances the functionality and specificity of the resulting conjugates, making them useful in research, diagnostics, and therapeutic applications.
Used in Drug Delivery Systems:
Alpha-amine-omega-propionic acid octaethylene glycol is utilized as a component in the design of drug delivery systems, such as nanoparticles, liposomes, or hydrogels. Its presence in these systems can improve the stability, solubility, and controlled release of therapeutic agents, leading to enhanced efficacy and reduced side effects.
Used in Diagnostics:
In the diagnostics industry, alpha-amine-omega-propionic acid octaethylene glycol is employed as a key component in the development of imaging agents and biosensors. Its reactivity with various functional groups allows for the attachment of contrast agents or signaling molecules, enabling the detection and monitoring of biological processes at the molecular level.
Used in Material Science:
In the field of material science, alpha-amine-omega-propionic acid octaethylene glycol is used as a building block for the synthesis of novel biocompatible materials, such as hydrogels, polymers, or surfaces with tailored properties. Its incorporation into these materials can enhance their biocompatibility, stability, and ability to interact with biological systems, making them suitable for various applications, including tissue engineering, regenerative medicine, and controlled cell culture.
Check Digit Verification of cas no
The CAS Registry Mumber 756526-04-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,6,5,2 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 756526-04:
(8*7)+(7*5)+(6*6)+(5*5)+(4*2)+(3*6)+(2*0)+(1*4)=182
182 % 10 = 2
So 756526-04-2 is a valid CAS Registry Number.
756526-04-2Relevant articles and documents
Optimization of IEDDA bioorthogonal system: Efficient process to improve trans-cyclooctene/tetrazine interaction
Béquignat, Jean-Baptiste,Boucheix, Claude,Canitrot, Damien,Chezal, Jean-Michel,Degoul, Fran?oise,Miot-Noirault, Elisabeth,Moreau, Emmanuel,Navarro-Teulon, Isabelle,Quintana, Mercedes,Rondon, Aurélie,Taiariol, Ludivine,Ty, Nancy
, (2020/07/21)
The antibody pretargeting approach for radioimmunotherapy (RIT) using inverse electron demand Diels-Alder cycloaddition (IEDDA) constitutes an emerging theranostic approach for solid cancers. However, IEDDA pretargeting has not reached clinical trial. The major limitation of the IEDDA strategy depends largely on trans-cyclooctene (TCO) stability. Indeed, TCO may isomerize into the more stable but unreactive cis-cyclooctene (CCO), leading to a drastic decrease of IEDDA efficiency. We have thus developed both efficient and reproducible synthetic pathways and analytical follow up for (PEGylated) TCO derivatives, providing high TCO isomeric purity for antibody modification. We have set up an original process to limit the isomerization of TCO to CCO before the mAbs’ functionalization to allow high TCO/tetrazine cycloaddition.
