75722-64-4

Basic information

• Product Name: Pyridine, 2-(2,4,6-trimethylphenyl)-
• CAS NO: 75722-64-4
• Molecular Formula: C14H15N
• Molecular Weight: 197.28
• Mol File: 75722-64-4.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(2,4,6-trimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(2,4,6-trimethylphenyl)-(75722-64-4)
• EPA Substance Registry System: Pyridine, 2-(2,4,6-trimethylphenyl)-(75722-64-4)

Safety Data

• Hazardous Substances Data: 75722-64-4(Hazardous Substances Data)

Upstream product

• 4028-63-1 iodomesitylene 
• 85311-89-3 2-pyridylcopper 
• 109-09-1 2-chloropyridine 
• 2633-66-1 2-mesitylmagnesium bromide 
• 4467-06-5 2-(4-methylphenyl)pyridine 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 3385-78-2 trimethyl indium 
• 109-04-6 2-bromo-pyridine 
• 5029-67-4 2-iodopyridine 
• 108-67-8 1,3,5-trimethyl-benzene 
• 55499-44-0 2,4-dimethylbenzeneboronic acid 
• 914253-86-4 2-(2,4-dimethylphenyl)pyridine 
• 5980-97-2 mesitylboronic acid 
• 1628-89-3 2-methoxypyridine 

Downstream Products

• 1383625-71-5 methyl 2-{3,5-dimethyl-2-(pyridin-2-yl)phenyl}acetate 
• 1383625-70-4 dimethyl 2,2'-{5-methyl-2-(pyridin-2-yl)-1,3-phenylene}diacetate 

Relevant articles and documents

Cobalt-Catalyzed Kumada Coupling Forming Sterically Encumbered C-C Bonds

A Co(acac)3/PN precatalyst was developed and optimized for catalytic Kumada coupling of aryl Grignard reagents to sterically encumbered alkyl halides. The substrate scope demonstrates excellent yields for primary alkyl chlorides and bromides, including good performance using neopentyl chloride and neophyl chloride. Secondary alkyl halides were also successfully arylated in good yields, and the presence of β-hydrogen atoms in a substrate did not inhibit product formation. An intermolecular functional group tolerance screen was conducted which indicates that ester and amide functionality are well tolerated by the reaction conditions. Electrophiles containing ester, pyridine, and nitrile functionality were all coupled with 2-mesitylmagnesium bromide in good yields, supporting tolerance screen results. The intermolecular screen also showed that functional groups which are typically reactive with Grignard reagents such as alcohols and terminal alkynes were not well-tolerated by the reaction.

Palladium (II) Complexes Containing 2-Phenylpyridine Derivatives: Synthesis, Molecular Structures, and Catalytic Activity for Suzuki–Miyaura Cross-Coupling Reactions

The preparation and characterization of a series of new 2-phenylpyridine derivative ligands consisting of 2-(R) pyridine (R = mesityl (L1), 2,6-dimethylphenyl (L2), o-tolyl (L3), m-tolyl (L4), p-tolyl (L5), o-methoxyphenyl (L6), and p-methoxyphenyl (L7)) and their Pd complexes [PdCl2L2] (L1–L7) is investigated using a combination of X-ray diffraction spectroscopy, GC-MS, and NMR. The crystal structures show that the Pd complexes adopt a square planar geometry, and the monodentate ligand is coordinated through the N donor of the pyridine ring to the Pd atom. The catalytic activities of the synthesized complexes are investigated. The square planar Pd complex trans-[(2-mesitylpy)2PdCl2)] shows a high efficiency in promoting Suzuki-Miyaura cross coupling in an aqueous solvent under aerobic conditions.

Palladium-Catalyzed Electrochemical C-H Alkylation of Arenes

Palladium-catalyzed electrochemical C-H functionalization reactions have emerged as attractive tools for organic synthesis. This process offers an alternative to conventional methods that require harsh chemical oxidants. However, this electrolysis requires divided cells to avoid catalyst deactivation by cathodic reduction. Herein, we report the first example of palladium-catalyzed electrochemical C-H alkylation of arenes using undivided electrochemical cells in water, thereby providing a practical solution for the introduction of alkyl groups into arenes.