7600-00-2Relevant articles and documents
Facile Synthesis of Azaarene-Substituted Hydroxycoumarins Possessing High Biological Activities via Three-Component C(sp3)-H Functionalization
Dong, Haoxun,Xu, Lubin,Li, Shuai-Shuai,Wang, Liang,Shao, Chang-Lun,Xiao, Jian
, p. 604 - 610 (2016)
An unprecedented three-component C(sp3)-H functionalization of 2-alkylazaarenes with aryl aldehydes and 4-hydroxycoumarins was realized, providing azaarene-substituted 3-benzyl-4-hydroxycoumarins in good to excellent yields. These new target compounds displayed broad-spectrum antibacterial activities, providing a new type of antibacterial skeleton.
One-pot two-step mechanochemical synthesis of arylsulfonyl 4H-pyrans
Cheng, Yue,Chu, Xiaohe,Huang, Qianqian,Jiang, Ling,Lu, Qingqing
, (2022/02/14)
In this paper, a simple and environment-friendly protocol was developed for the synthesis of arylsulfonyl 4H-pyrans via L-proline-catalyzed one-pot two-step reaction of aromatic aldehyde with phenylsulphonyl acetonitrile and dimedone under ball-milling conditions. Environmental acceptability, wide substrate scope, low cost and operational simplicity are the key features of this method.
Montmorillonite KSF-Catalyzed Synthesis of 2,2′-(Arylmethylene)bis(3-hydroxy-5,5-dimethylcyclohex-2-en-1-ones) for the Functionalization of MCM-41 Silica Nanoparticles
Mechi, L.,Mosbah, M. Ben,Moussaoui, Y.
, p. 1533 - 1539 (2021/10/26)
Abstract: A green protocol has been developed for the preparation of 2,2′-(arylmethylene)bis(3-hydroxy-5,5-dimethylcyclohex-2-en-1-ones) following the multicomponent condensation reaction between aromatic alde-hydes and dimedone with excellent yields. The
On the enantioselective phosphoric-acid-catalyzed hantzsch synthesis of polyhydroquinolines
Bonne, Damien,Bressy, Cyril,Bugaut, Xavier,Constantieux, Thierry,Jean, Marion,Lemaitre, Clément,Quinonero, Ophélie,Rodriguez, Jean,Roussel, Christian,Vanthuyne, Nicolas
supporting information, p. 3394 - 3398 (2021/05/29)
A reinvestigation of a chiral phosphoric-acid-catalyzed four-component Hantzsch enantioselective synthesis of polyhydroquinolines reported in 2009 is presented. In our hands, when the reaction was performed with fidelity to the original report using a chiral enantiopure phosphoric acid catalyst, no enantioselectivity was observed. Unlike in the original report, enantioselectivity results are backed by baseline separation of the enantiomers by HPLC analyses on chiral stationary phase with UV and chiroptical detection.