76385-35-8Relevant articles and documents
MACROCYCLIC FLU ENDONUCLEASE INHIBITORS
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Page/Page column 44; 45, (2020/05/19)
The present invention relates to macrocyclic pyridotriazine derivatives of formula (I) and the pharmaceutically acceptable salts, solvates or or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae famiIy. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.
Cp*Co(III)-Catalyzed γ-Selective C-H Allylation/Hydroamination Cascade for the Synthesis of Dihydroisoquinolines
Choi, Suh Young,Kim, Hyeon Dae,Park, Jong-Un,Park, Sun-A,Kim, Ju Hyun
supporting information, p. 10038 - 10042 (2019/12/24)
A Cp*Co(III)-catalyzed γ-selective C-H allylation/hydroamination cascade toward the synthesis of 3,4-dihydroisoquinolines (DHIQs) has been successfully developed, starting from NH ketimines and allyl carbonates. Notably, highly efficient and γ-selective C-H allylations were accomplished using γ-substituted allyl reagents, thus overcoming the issues of poor α/γselectivity and low reactivity of previous transition metal-catalyzed C-H allylations. The stereochemistry of allyl carbonates was a crucial factor, and synthesis of the DHIQs was achieved using (Z)-allyl carbonates.
Weakly Coordinating, Ketone-Directed Cp?Co(III)-Catalyzed C-H Allylation on Arenes and Indoles
Sk, Md Raja,Bera, Sourav Sekhar,Maji, Modhu Sudan
supporting information, p. 134 - 137 (2018/01/17)
Weakly coordinating, ketone-directed, regioselective monoallylation of arenes and indoles is reported using a stable and cost-effective high-valent cobalt(III)-catalyst to access several important molecular building blocks. The allylation proceeds smoothl
