764-52-3 Usage
Description
TRIFLUOROMETHIONINE is an L-alpha-amino acid, methionine, with the S-methyl group trifluoro-substituted. It is a modified form of the naturally occurring amino acid methionine, where three fluorine atoms replace the hydrogen atoms on the sulfur atom.
Uses
Used in Pharmaceutical Industry:
TRIFLUOROMETHIONINE is used as a pharmaceutical intermediate for the synthesis of various drugs and active pharmaceutical ingredients. Its unique trifluoromethyl group provides specific properties that can enhance the activity and selectivity of the final drug product.
Used in Chemical Synthesis:
TRIFLUOROMETHIONINE is used as a building block in the synthesis of complex organic molecules and compounds. Its trifluoromethyl group can impart unique reactivity and stability to the synthesized products, making it a valuable component in organic chemistry.
Used in Biochemical Research:
TRIFLUOROMETHIONINE is used as a research tool in biochemical studies to investigate the role of methionine and its derivatives in various biological processes. Its trifluoromethyl group can provide insights into the effects of fluorination on protein structure, function, and stability.
Used in Agrochemical Industry:
TRIFLUOROMETHIONINE can be used as a precursor in the synthesis of agrochemicals, such as herbicides, insecticides, and fungicides. Its unique properties can contribute to the development of more effective and environmentally friendly agrochemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 764-52-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,6 and 4 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 764-52:
(5*7)+(4*6)+(3*4)+(2*5)+(1*2)=83
83 % 10 = 3
So 764-52-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H8F3NO2S/c6-5(7,8)12-2-1-3(9)4(10)11/h3H,1-2,9H2,(H,10,11)/t3-/m0/s1
764-52-3Relevant articles and documents
Robust synthesis of trifluoromethionine and its derivatives by reductive trifluoromethylation of amino acid disulfides by CF3I/Na/Liq.NH 3 system
Yasui, Hiroyuki,Yamamoto, Takeshi,Tokunaga, Etsuko,Shibata, Norio
, p. 186 - 189 (2011)
We disclose the reductive trifluoromethylation of chemically stable homocystine and cystine to provide corresponding trifluoromethyl ethers by the CF3I/Na/Liq.NH3 system. Both non-protected and protected homocystines can be nicely converted into trifluoromethylated methionines under the same condition. The method described offers a robust synthesis of pharmaceutically important trifluoromethionine, suitable for multigram synthesis. Pentafluoroethylation of homocystine was also achieved by the CF 3CF2I/Na/Liq.NH3 system.
Simple preparation of trifluoromethionine and derivatives thereof
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Page/Page column 4, (2011/02/18)
Disclosed is a process for the simple preparation of trifluoromethionine, its analogs trifluoromethylcysteine, fluoroalkylhomocysteines, and fluoroalkylcysteines, and derivatives of them. These compounds are drug-candidate compounds or raw materials of drug-candidate compounds. Specifically, trifluoromethionine, trifluoromethylcysteine, a fluoroalkylhomocysteine, or a fluoroalkylcysteine is simply and conveniently prepared directly without passing through homocysteine or cysteine by adding metallic sodium to an optically active or racemic homocystine or cystine in liquid ammonia and further adding a fluoroalkyl iodide thereto under Birch reduction conditions.