76480-99-4 Usage
Description
5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3(2H)-ONE is an organic compound with the molecular formula C5H4F3NO. It is a derivative of pyrazole, a five-membered heterocyclic compound containing both nitrogen and oxygen atoms. The presence of a trifluoromethyl group (-CF3) attached to the 5th position of the pyrazole ring gives this compound unique chemical and biological properties.
Uses
Used in Pharmaceutical Industry:
5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3(2H)-ONE is used as a key intermediate in the synthesis of various Acyclic Pyrazole Sulfur Heterocyclic compounds. These compounds have potential applications as Uric Acid reabsorption inhibitors, which can be beneficial in the treatment of hyperuricemia and gout.
In the preparation of these heterocyclic compounds, 5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3(2H)-ONE serves as a building block, providing a foundation for the development of new drugs with improved efficacy and selectivity. Its unique structure allows for further chemical modifications and functionalization, enabling the creation of a diverse range of therapeutic agents.
Additionally, the trifluoromethyl group in this compound may contribute to enhanced lipophilicity and metabolic stability, which can be advantageous for drug design and development. As a result, 5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3(2H)-ONE holds significant potential in the pharmaceutical industry for the development of novel therapeutic agents targeting uric acid-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 76480-99-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,4,8 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 76480-99:
(7*7)+(6*6)+(5*4)+(4*8)+(3*0)+(2*9)+(1*9)=164
164 % 10 = 4
So 76480-99-4 is a valid CAS Registry Number.
76480-99-4Relevant articles and documents
Synthesis of 3-hydroxy-5-per(poly)fluoroalkyl pyrazoles
Hu, Qiao-Sheng,Guan, Hui-Ping,Hu, Chang-Ming
, p. 51 - 54 (1995)
Treatment of ethyl α-per(poly)fluoroalkyl acetates 1 or ethyl α-iodo-β-per(poly)fluoroalkyl acrylates 2 with hydrazine gives 3-hydroxy-5-per(poly)fluoroalkyl pyrazoles 3 in excellent yield.The effect of halogens on the per(poly)fluoroalkyl chain and the reaction conditions were studied. - Keywords: Synthesis; Hydroxyper(poly)fluoroalkyl pyroles; NMR spectroscopy; IR spectroscopy; Mass spectrometry
PYRAZOLE DERIVATIVE, INTERMEDIATE THEREFOR, PROCESSES FOR PRODUCING THESE, AND HERBICIDE CONTAINING THESE AS ACTIVE INGREDIENT
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Page/Page column 16-17, (2010/11/30)
The present invention provides a pyrazole derivative of the general formula (1), which has an excellent efficacy as an active component for a herbicide, an intermediate for the production thereof, processes for the production thereof, and a herbicide cont
Synthesis of Fluorinated Analogues of Geraniol
Poulter, C. Dale,Wiggins, Paul L.,Plummer, Thomas L.
, p. 1532 - 1538 (2007/10/02)
Syntheses of 3-(fluoromethyl)geraniol (4), 3-(difluoromethyl)geraniol (14), and 3-(trifluoromethyl)geraniol (20) are described.The key reaction in the routes to alcohols 4 and 20 which establishes the geranyl Z stereochemistry at the C(2)-C(3) double bond is the cis addition of (4-methylpent-3-en-1-yl)copper reagents to derivatives of ethyl 2-butynoate bearing appropriate functional groups at C(4).Attempts to prepare difluoromethyl alcohol 14 by similar routes were unsuccessful.However, the carbon skeleton of 14 was constructed by a Wittig condensation of 1,1-difluoro-6-methylhept-5-en-2-one (12) with triethyl phosphonoacetate in a reaction that yielded a 72:28 ratio of geranyl/neryl isomers.
