76732-76-8

Basic information

• Product Name: 2-(tetrahydro-2-thienyl)pyridine
• Synonyms: 2-[(Tetrahydrothiophen)-2-yl]pyridine;2-(tetrahydro-2-thienyl)pyridine
• CAS NO: 76732-76-8
• Molecular Formula: C₉H₁₁NS
• Molecular Weight: 165.25534
• EINECS: 278-533-5
• Mol File: 76732-76-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 297.4°C at 760 mmHg
• Flash Point: 133.7°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 0.00239mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: 2-(tetrahydro-2-thienyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tetrahydro-2-thienyl)pyridine(76732-76-8)
• EPA Substance Registry System: 2-(tetrahydro-2-thienyl)pyridine(76732-76-8)

Safety Data

• Hazardous Substances Data: 76732-76-8(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic

Structure

Pyridine ring with a tetrahydro-2-thienyl substituent

Usage

Synthesis of pharmaceuticals and agrochemicals

Potential biological activity

Anti-inflammatory and antioxidant properties

Role in organic synthesis

Building block

Importance

Potential to be an important compound in various areas of research and development.

InChI:InChI=1/C9H11NS/c1-2-6-10-8(4-1)9-5-3-7-11-9/h1-2,4,6,9H,3,5,7H2

Upstream product

• 76732-77-9 3-chloropropyl 2-pyridylmethyl sulfide 
• 2044-73-7 2-(sulfanylmethyl)pyridine 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 1822-49-7 2-(2-pyridylmethyl)isothiourea dihydrochloride 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 104489-64-7 2-Pyridin-2-yl-tetrahydro-thiophene-2-carbothioic acid phenylamide 
• 76732-75-7 N-methyl-2-(2-pyridyl)tetrahydrothiophene-2-carbothioamide 
• 76743-03-8 2-Pyridin-2-yl-tetrahydro-thiophene-2-carbothioic acid benzylamide 

Relevant articles and documents

Synthesis and Antisecretory and Antiulcer Activities of Derivatives and Analogues of 2-(2-Pyridyl)tetrahydrothiophene-2-carbothioamide

New thioamide derivatives of 2-(2-pyridyl)tetrahydrothiophene-2-carbothioamide (29) and related compounds (in which the tetrahydrothiophene ring was replaced by tetrahydrothiopyran, tetrahydrofuran, 1,3-dithiane, or 1,3-oxathiane and where the pyridine ring was repleaced by other nitrogen heterocycles) were synthesized and tested for their antisecretory and antiulcer activities.These thioamides were prepared according to one of the following methods: (i) reaction of an isothiocyanate with the carbanion of the corresponding cyclic precursor (for secondary thioamides); (ii) reaction of ammonia or an amine with the dithio ester prepared from the same precursor (for primary, secondary, and tertiary thioamides).These thioamides were evaluated by the Shay method to measure their antisecretory activity and by the stress-induced-ulcer method to test their antiulcer activity.Structure-activity relationships are discussed.N-Methyl-2-(2-pyridyl)tetrahydrothiophene-2-carbothioamide (R.P. 40749,30) exhibited activities that were at least 10 times higher than those reported for cimetidine.