769-60-8Relevant articles and documents
A Novel Synthesis of β-Trichlorostannyl Ketones from Siloxycyclopropanes and Their Facile Dehydrostannation Affording 2-Methylene Ketones
Ryu, Ilhyong,Murai, Shinji,Sonoda, Noboru
, p. 2389 - 2391 (1986)
Site-selective ring cleavage of siloxycyclopropanes 2 with stannic chloride (SnCl4) leads to good yields of β-trichlorostannyl ketones 3.Subsequent treatment of 3 with dimethyl sulfoxide (Me2SO) in chloroform at 60 deg C results in the facile dehydrostannation to give good yields of 2-methylene ketones 4.
Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents
Feng, Xiaoming,He, Qianwen,Liu, Xiaohua,Zhang, Dong,Zhang, Fengcai
supporting information, p. 6961 - 6966 (2021/09/11)
An enantioselective epoxidation of α-substituted vinyl ketones was realized to construct the key epoxide intermediates for the synthesis of various triazole antifungal agents. The reaction proceeded efficiently in high yields with good enantioselectivities by employing a chiral N,N′-dioxide/ScIII complex as the chiral catalyst and 35% aq. H2O2 as the oxidant. It enabled the facile transformation for optically active isavuconazole, efinaconazole, and other potential antifungal agents.
Nickel-Catalyzed C(sp3)-H Functionalization of Benzyl Nitriles: Direct Michael Addition to Terminal Vinyl Ketones
Zhang, Ninghui,Zhang, Chunli,Hu, Xiaoping,Xie, Xin,Liu, Yuanhong
supporting information, p. 6004 - 6009 (2021/07/31)
An efficient nickel(0)-catalyzed addition of benzyl nitriles to terminal vinyl ketones via C(sp3)-H functionalization has been developed. The reaction provides a novel and efficient protocol for the synthesis of α-functionalized benzyl nitriles with a wide range of structural diversity under mild reaction conditions while obviating the use of a strong base. The work might be potentially useful toward the development of an enantioselective variant using chiral nitrogen ligands.