7725-93-1

Basic information

• Product Name: 1-(2,3-dihydro-4-methyl-2-thioxothiazol-5-yl)ethan-1-one
• Synonyms: 1-(2,3-dihydro-4-methyl-2-thioxothiazol-5-yl)ethan-1-one;1-[(2,3-Dihydro-4-methyl-2-thioxothiazol)-5-yl]ethanone;5-Acetyl-4-methylthiazole-2-thiol
• CAS NO: 7725-93-1
• Molecular Formula: C₆H₇NOS₂
• Molecular Weight: 173.25588
• EINECS: 231-772-9
• Mol File: 7725-93-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 295.7°Cat760mmHg
• Flash Point: 132.6°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 0.0015mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: 1-(2,3-dihydro-4-methyl-2-thioxothiazol-5-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-dihydro-4-methyl-2-thioxothiazol-5-yl)ethan-1-one(7725-93-1)
• EPA Substance Registry System: 1-(2,3-dihydro-4-methyl-2-thioxothiazol-5-yl)ethan-1-one(7725-93-1)

Safety Data

• Hazardous Substances Data: 7725-93-1(Hazardous Substances Data)

Usage

Reactivity Profile

1-(2,3-dihydro-4-methyl-2-thioxothiazol-5-yl)ethan-1-one is an organosulfide/ketone. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

Fire Hazard

Flash point data for 1-(2,3-dihydro-4-methyl-2-thioxothiazol-5-yl)ethan-1-one are not available. 1-(2,3-dihydro-4-methyl-2-thioxothiazol-5-yl)ethan-1-one is probably combustible.

InChI:InChI=1/C6H7NOS2/c1-3-5(4(2)8)10-6(9)7-3/h1-2H3,(H,7,9)

Upstream product

• 513-74-6 ammonium dithiocarbamate 
• 81447-35-0 2,4-dioxopentan-3-yl 4-methylbenzenesulfonate 
• 1093106-54-7 1-(2-bromo-4-methylthiazol-5-yl)ethan-1-one 
• 75-15-0 carbon disulfide 
• 1694-29-7 3-chloropentane-2,4-dione 
• 123-54-6 acetylacetone 
• 30748-47-1 5-acetyl-4-methylthiazole-2-amine 

Relevant articles and documents

Synthesis, X-ray analysis, biological evaluation and molecular docking study of new thiazoline derivatives

A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing1H-NMR,13C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.

Azole derivatives as histamine H3 receptor antagonists, Part 2: C-C and C-S coupled heterocycles

With a small series of compounds we demonstrated the variability in the core region of the human histamine H3 receptor (hH3R) antagonist structural blueprint by introducing polar azole groups (oxazole, oxadiazole, thiazole and triazole). Additional variations achieved by coupling different residues to the heterocyclic core structure led to further optimisation of in vitro receptor binding of the novel azole derivatives.

A facile synthesis of thiazole-2(3H)-thiones through [hydroxy(tosyloxy) iodo]benzene

A one-pot facile synthesis of thiazole-2(3H)-thiones (4) has been achieved by hypervalent iodine oxidation of ketones (1) using [hydroxy (tosyloxy)iodo]benzene, followed by the treatment of the reaction mixture with dithiocarbamate salts (3) The intermediate α-tosyloxy-ketones (2) have also been isolated and converted to the target compounds.