77350-93-7 Usage
Description
1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-3-methylis a chemical compound belonging to the purine family. It is characterized by its unique molecular structure, which features a 8-chloro substitution and a 3-methyl group attached to a 3,7-dihydro-1H-purine-2,6-dione core. 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-3-methylis known for its potential applications in the pharmaceutical industry due to its ability to inhibit certain enzymes, making it a promising candidate for the development of new drugs.
Uses
Used in Pharmaceutical Industry:
1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-3-methylis used as a key intermediate compound in the synthesis of Aminopiperidinylxanthines. These xanthine derivatives are known as Dipeptidylpeptidase-IV (DPP-IV) inhibitors, which play a crucial role in the treatment of type 2 diabetes. DPP-IV inhibitors help regulate blood sugar levels by reducing the rate at which certain hormones are broken down, thus improving the body's response to insulin and maintaining glucose homeostasis.
In the preparation of Aminopiperidinylxanthines, 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-3-methylserves as a valuable building block for the development of novel DPP-IV inhibitors with improved pharmacological properties, such as enhanced potency, selectivity, and reduced side effects. This application highlights the importance of this compound in the ongoing efforts to develop more effective treatments for type 2 diabetes and related metabolic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 77350-93-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,3,5 and 0 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 77350-93:
(7*7)+(6*7)+(5*3)+(4*5)+(3*0)+(2*9)+(1*3)=147
147 % 10 = 7
So 77350-93-7 is a valid CAS Registry Number.
77350-93-7Relevant articles and documents
Xanthine derivatives as DPP-IV inhibitors
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, (2008/06/13)
The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, and R42 each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, which group may be substituted; and, R1 and R2 each independently represents a hydrogen atom, an alkyl group, an alkoxyl group, or such, or salts or hydrates thereof.
ELECTROPHILIC AND NUCLEOPFILIC SUBSTITUTION REACTION IN THE SERIES OF 3-METHYLXANTHINE AND ITS DERIVATIVES
Priimenko, B.A.,Romanenko, N.I.,Klyuev, N.A.,Fedulova, I.V.,Gnatov, N.I.,Garmash, S.N.
, p. 924 - 927 (2007/10/02)
The reactions of nitration and bromination of 3-methylxanthine were studied.Heating 3-methyl-8-nitroxanthine with con.HCl and HBr leads to a replacement of the nitro group by a halogen atom.The alkylation of 8-haloxanthines by alkyl halides were studied.It was shown that boiling 7-substituted 3-methyl-8-bromoxanthine derivatilves with POCl3 and PCl5 leads to the formation of 2,6,8-trichloro-7-alkylpurines.The structure of synthetized compounds was confirmed by counter synthesis, the data of elementary analysis, and mass spectrometry.
