774596-24-6

Basic information

• Product Name: Isoniazid-D4
• Synonyms: Isoniazid-D4;4-Pyridine-2,3,5,6-d4-carboxylic Acid Hydrazide;FSR-3-d;Isonicotinylhydrazine-d4;RP-5015-d4;Tubazid-d4;(4-Pyridine-2,3,5,6-D-carboxylic Acid Hydrazide;FSR-3-d3
• CAS NO: 774596-24-6
• Molecular Formula: C6H3D4N3O
• Molecular Weight: 137.14
• Product Categories: Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Amines;Aromatics;Isotope Labelled Compounds
• Mol File: 774596-24-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 171.40C
• Appearance: /
• Density: 1.281g/cm³
• Refractive Index: 1.584
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Isoniazid-D4(CAS DataBase Reference)
• NIST Chemistry Reference: Isoniazid-D4(774596-24-6)
• EPA Substance Registry System: Isoniazid-D4(774596-24-6)

Safety Data

• Hazardous Substances Data: 774596-24-6(Hazardous Substances Data)

Usage

Description

Isoniazid-D4 is a crystalline solid that is a labeled and deuterated analog of Isoniazid, an antibiotic used for the treatment of Mycobacterium tuberculosis. It is characterized by its ability to inhibit mycolic acid biosynthesis, which is essential for the growth and survival of the bacteria.

Uses

Used in Pharmaceutical Industry:
Isoniazid-D4 is used as an antibiotic for the treatment of Mycobacterium tuberculosis. It functions by inhibiting mycolic acid biosynthesis, which is crucial for the growth and survival of the bacteria. This makes it an essential component in the fight against tuberculosis.
Additionally, Isoniazid-D4 is used as a research tool in the study of the metabolism and toxic effects of Isoniazid. It is metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Isoniazid-D4 also selectively induces the expression of CYP2E1 and reversibly inhibits the activities of CYP2C19 and CYP3A4. Furthermore, Isoniazid-D4 has been shown to mechanistically inactivate CYP1A2, CYP2A6, CYP2C19, and CYP3A4 at clinically relevant concentrations, making it a valuable compound for understanding the complex interactions between drugs and the enzymes involved in their metabolism.
Used in Bacterial Infection Treatment:
Isoniazid-D4 is used as an antibacterial agent, specifically for its tuberculostatic properties. This means that it is effective in inhibiting the growth and reproduction of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis. Its use in this context is crucial for the development of effective treatment strategies for this infectious disease.

InChI:InChI=1/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)/i1D,2D,3D,4D