77463-79-7

Basic information

• Product Name: Phenol, 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[4,6-dichloro-
• CAS NO: 77463-79-7
• Molecular Formula: C16H12Cl4N2O2
• Molecular Weight: 406.095
• Mol File: 77463-79-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Phenol, 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[4,6-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[4,6-dichloro-(77463-79-7)
• EPA Substance Registry System: Phenol, 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[4,6-dichloro-(77463-79-7)

Safety Data

• Hazardous Substances Data: 77463-79-7(Hazardous Substances Data)

Upstream product

• 107-15-3 ethylenediamine 
• 90-60-8 3,5-dichlorosalicyclaldehyde 

Downstream Products

• 188482-95-3 VO⁽²⁺⁾*C₁₆H₁₀Cl₄N₂O₂^(2-) = [VO(C₁₆H₁₀Cl₄N₂O₂)] 

Relevant articles and documents

Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors

In this report, we designed and synthesized a series of cobalt(II)-Schiff base complexes (CoSBC) with competent MEK1 (mitogen-activated protein kinase kinase?1) inhibitory activity. Based on our previous report, the CoSBC exhibited high binding affinity with MEK1 protein. To further explore metal complexes as MEK1 inhibitors, a series of transition metals and ligands were employed to build a library of various metal Schiff base complexes. The MEK inhibition assays revealed that only CoSBC exhibited obvious inhibitory activity, complex 2b showed the best inhibition both in BRaf (B-rapidly accelerated fibrosarcoma)/MEK1 and MEK1/ERK2 (extracellular signal-regulated kinases-2) cascading (IC50 is 1.988 ± 0.14 μM and 1.589 ± 0.054 μM respectively). In addition, homogeneous time-resolved fluorescence test method was used to prove that CoSBC as ATP-noncompetitive MEK1 inhibitor. MEK kinase selectivity assay indicated that CoSBC can selectively inhibit MEK1/2 kinases rather than other MAPKs (mitogen-activated protein kinases) family kinases. Moreover, the interaction mode of 2b with MEK1 protein has been demonstrated by computer aided drug design.

Schiff base iron compound, preparation method thereof and application of Schiff base iron compound as catalyst

The invention provides a Schiff base iron compound, a preparation method thereof and application of the Schiff base iron compound as a catalyst. The Schiff base iron compound has a structure represented by a formula (I) (shown in the description), wherein

Electrochemical properties of VO salen complexes

Electrochemical properties of a series of differently substituted vanadyl salen complexes were investigated using cyclic voltammetry in different solvents. Results obtained show that the salen structure stabilizes the oxidized forms and that the effects of substituents on the oxidation potential correlate with the electronic density of the metal. Also the role of the donicity of the solvent in influencing the redox potentials of the studied complexes has been evidenced. Moreover, the variations of the observed potentials can be qualitatively correlated to the catalytic activity of vanadyl salen derivatives in the oxidation of thioethers.