77731-11-4 Usage
Description
(5beta,7alpha,12alpha)-7,12-Dihydroxychol-3-en-24-oic acid methyl ester, also known as ursodiol, is a bile acid derivative that plays a crucial role in the management of liver and gallbladder conditions. It functions by decreasing the liver's cholesterol production and aiding in the dissolution of gallstones. Ursodiol is also utilized for preventing gallstone formation in individuals experiencing rapid weight loss or those who have undergone gastric bypass surgery. Furthermore, it has been investigated for its potential impact on other health conditions, such as primary biliary cholangitis and nonalcoholic fatty liver disease. (5beta,7alpha,12alpha)-7,12-Dihydroxychol-3-en-24-oic acid methyl ester is available in both oral and injectable forms and is generally well-tolerated with minimal adverse effects.
Uses
Used in Pharmaceutical Industry:
Ursodiol is used as a therapeutic agent for the treatment of liver and gallbladder conditions, specifically reducing cholesterol production in the liver and dissolving gallstones. Its application aids in managing and improving the health of patients suffering from these conditions.
Used in Weight Loss Management:
Ursodiol is used as a preventive measure for gallstone formation in patients who are undergoing rapid weight loss or have had gastric bypass surgery. This application helps to mitigate the risk of developing gallstones during significant weight loss processes.
Used in Research and Development:
Ursodiol is utilized in research studies exploring its potential effects on other health conditions, such as primary biliary cholangitis and nonalcoholic fatty liver disease. This application contributes to the advancement of medical knowledge and the development of new treatment options for these diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 77731-11-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,7,3 and 1 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 77731-11:
(7*7)+(6*7)+(5*7)+(4*3)+(3*1)+(2*1)+(1*1)=144
144 % 10 = 4
So 77731-11-4 is a valid CAS Registry Number.
77731-11-4Relevant articles and documents
Potential Bile Acid Metabolites. 8. 7,12-Dihydroxy- and 7β-Hydroxy-5β-cholanic Acids
Iida, Takashi,Chang, Frederic C.
, p. 1194 - 1197 (1983)
Syntheses of 7β-hydroxy- and the stereoisomeric 7,12-dihydroxycholanic acids, their methyl esters, and some related derivatives are described. 12α-Mesyloxy groups, unlike their 7α analogues, were found to be resistant to KO2-crown ether inversion.
A mild one-pot method for conversion of various steroidal secondary alcohols into the corresponding olefins
Kumar, Raju Ranjith,Haveli, Shrutisagar Dattatraya,Kagan, Henri B.
experimental part, p. 1709 - 1712 (2011/09/14)
The addition of Tf2O to some hydroxy steroids in the presence of excess base directly leads to steroidal olefins. This methodology is useful for the one-pot synthesis of Δ2- or Δ3-steroids under mild conditions from the corresponding alcohols. Georg Thieme Verlag Stuttgart · New York.
Olefins of the cholane series from deoxycholic and cholic acids
Brieskorn,Mosandl
, p. 118 - 127 (2007/10/02)
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